Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
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Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virusIdentification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming geneThe E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein.Structural role of the conserved cysteines in the dimerization of the viral transmembrane oncoprotein E5.The E5 proteinsQuantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle.Multiple transmembrane amino acid requirements suggest a highly specific interaction between the bovine papillomavirus E5 oncoprotein and the platelet-derived growth factor beta receptor.Papillomavirus E5: the smallest oncoprotein with many functions.Biologically active LIL proteins built with minimal chemical diversity.Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein.Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cellsMutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variantsThe genomes of the animal papillomaviruses European elk papillomavirus, deer papillomavirus, and reindeer papillomavirus contain a novel transforming gene (E9) near the early polyadenylation site.The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes.Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domainThe human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamineRegulation of the C/EBP-related gene gadd153 by glucose deprivation.Identification and genetic definition of a bovine papillomavirus type 1 E7 protein and absence of a low-copy-number phenotype exhibited by E5, E6, or E7 viral mutantsOpen reading frames E6 and E7 of bovine papillomavirus type 1 are both required for full transformation of mouse C127 cellsBiological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptorGenetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 proteinTransforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells.The conserved C-terminal domain of the bovine papillomavirus E5 oncoprotein can associate with an alpha-adaptin-like molecule: a possible link between growth factor receptors and viral transformationIdentification and characterization of the herpesvirus saimiri oncoprotein STP-C488.Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.Mutational analysis of bovine papillomavirus type 1 E5 peptide domains involved in induction of cellular DNA synthesis.44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acidsBovine papillomavirus E2 gene regulates expression of the viral E5 transforming geneLocalization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue.Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cellsBovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
P2860
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P2860
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
description
1987 nî lūn-bûn
@nan
1987 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@ast
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@en
type
label
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@ast
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@en
prefLabel
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@ast
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@en
P2093
P2860
P1433
P1476
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
@en
P2093
P2860
P304
P407
P577
1987-08-01T00:00:00Z