Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response - Wikidata - awgldk - TriplyDB

Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response

Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response

http://www.wikidata.org/entity/Q33930511

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Consensus on the role of human cytomegalovirus in glioblastoma The DNA damage response induced by infection with human cytomegalovirus and other viruses Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation New cell-signaling pathways for controlling cytomegalovirus replication.RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.Activation of H2AX and ATM in varicella-zoster virus (VZV)-infected cells is associated with expression of specific VZV genes Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Regulation of the retinoblastoma proteins by the human herpesviruses.Viral manipulation of DNA repair and cell cycle checkpoints Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.Is HCMV a tumor promoter?Interference with p53 functions in human viral infections, a target for novel antiviral strategies?The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.Human cytomegalovirus riding the cell cycle.Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5.Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.Frequent detection of human cytomegalovirus in neuroblastoma: a novel therapeutic target?Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomes Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2.Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice.The chromatin remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate-early promoter.The transcriptome of human mammary epithelial cells infected with the HCMV-DB strain displays oncogenic traits The Human Cytomegalovirus, from Oncomodulation to Oncogenesis

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Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response

http://www.wikidata.org/entity/Q33930511

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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JVI.79.17.11467-11475.2005

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Journal of Virology

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Human cytomegalovirus IE1-72 a ...... ediated growth arrest response

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P2093

Andrew D Yurochko

http://www.w3.org/2001/XMLSchema#string

Fiona M Frame

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Harry A Rogoff

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Jonathan P Castillo

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Mary T Pickering

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Timothy F Kowalik

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P2860

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

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11467-11475

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scholarly article

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10.1128/JVI.79.17.11467-11475.2005

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17

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79

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2005-09-01T00:00:00Z

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16103197

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Cytomegalovirus

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1193638

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