A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.
about
Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficitsOral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agentsTricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.Back to the future with phenotypic screeningSyntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's diseaseThe influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone moleculesAmyloid β1-42 oligomer inhibits myelin sheet formation in vitro.Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models.Design, synthesis, and evaluation of bioactive small molecules.Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.A broadly neuroprotective derivative of curcumin.Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficitsInsight into amyloid structure using chemical probes.Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons.Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's DiseaseSynthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors.Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology.Small molecule inhibitors of Abeta assembly.Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease.STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity.Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity.Bivalent Compound 17MN Exerts Neuroprotection through Interaction at Multiple Sites in a Cellular Model of Alzheimer's DiseaseLenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells.Congo red and thioflavin-T analogs detect Abeta oligomers.Vitamin B(12), a chlorophyll-related analog to pheophytin a from marine brown algae, promotes neurite outgrowth and stimulates differentiation in PC12 cells.Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity.The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.Bivalent ligands targeting multiple pathological factors involved in Alzheimer's diseaseFrom the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease.Effect of phenolic compounds against Aβ aggregation and Aβ-induced toxicity in transgenic C. elegans.Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta
P2860
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P2860
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A novel tricyclic pyrone compo ...... oid-beta oligomeric complexes.
@en
type
label
A novel tricyclic pyrone compo ...... oid-beta oligomeric complexes.
@en
prefLabel
A novel tricyclic pyrone compo ...... oid-beta oligomeric complexes.
@en
P2093
P2860
P1476
A novel tricyclic pyrone compo ...... oid-beta oligomeric complexes.
@en
P2093
Erik Pettersson
Gary A Radke
George M Martin
Hui-Chuan Wu
Hyun-Seok Hong
Izumi Maezawa
Lee-Way Jin
Sandeep Rana
Srinivas K Battina
P2860
P356
10.1111/J.1471-4159.2006.03862.X
P407
P577
2006-07-01T00:00:00Z