T-cell signaling regulated by the Tec family kinase, Itk.
about
Phosphoinositides: tiny lipids with giant impact on cell regulationExpression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in miceSelectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitorsAutoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide.In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell KinaseMolecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factorITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinaseIL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach.Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinasesDNA-methylation profiling distinguishes malignant melanomas from benign nevi.The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiationIL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive functionAlkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytesTargeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in MelanomaImmunoreceptor signalingDynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells.Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells.The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cellsInterleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for NotchInherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.
P2860
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P2860
T-cell signaling regulated by the Tec family kinase, Itk.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
T-cell signaling regulated by the Tec family kinase, Itk.
@ast
T-cell signaling regulated by the Tec family kinase, Itk.
@en
type
label
T-cell signaling regulated by the Tec family kinase, Itk.
@ast
T-cell signaling regulated by the Tec family kinase, Itk.
@en
prefLabel
T-cell signaling regulated by the Tec family kinase, Itk.
@ast
T-cell signaling regulated by the Tec family kinase, Itk.
@en
P2093
P2860
P1476
T-cell signaling regulated by the Tec family kinase, Itk.
@en
P2093
Amy H Andreotti
Leslie J Berg
Pamela L Schwartzberg
Raji E Joseph
P2860
P304
P356
10.1101/CSHPERSPECT.A002287
P577
2010-06-02T00:00:00Z