Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination.
about
Endogenous viral elements in animal genomesCircular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue.Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate modelAdeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNAAdeno-associated virus vector integrationLarge-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studiesAnalysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levelsAdeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genomeSecond-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectorsLong term physiologic modification using rAAV in utero gene-therapyIn utero recombinant adeno-associated virus gene transfer in mice, rats, and primatesRepair at single targeted DNA double-strand breaks in pluripotent and differentiated human cellsGene Therapy for Metabolic DiseasesGermline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virusRoles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombinationVirus-mediated gene transfer to induce therapeutic angiogenesis: where do we stand?Adeno-associated virus site-specifically integrates into a muscle-specific DNA regionIntegration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.Analysis of the effects of charge cluster mutations in adeno-associated virus Rep68 protein in vitroDevelopment of animal models for adeno-associated virus site-specific integration.Stable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19Complement yourself: Transcomplementation rescues partially folded mutant proteins.Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2.Rescue and autonomous replication of adeno-associated virus type 2 genomes containing Rep-binding site mutations in the viral p5 promoter.The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity.Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets.Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanismConditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates.Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteinsRepeated delivery of adeno-associated virus vectors to the rabbit airway.Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro.High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression.Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applicationsFunctional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.Characterization of adeno-associated virus genomes isolated from human tissues.Substitution of adeno-associated virus Rep protein binding and nicking sites with human chromosome 19 sequences.
P2860
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P2860
Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination.
description
1992 nî lūn-bûn
@nan
1992 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Characterization of a preferre ...... non-homologous recombination.
@ast
Characterization of a preferre ...... non-homologous recombination.
@en
type
label
Characterization of a preferre ...... non-homologous recombination.
@ast
Characterization of a preferre ...... non-homologous recombination.
@en
prefLabel
Characterization of a preferre ...... non-homologous recombination.
@ast
Characterization of a preferre ...... non-homologous recombination.
@en
P2093
P2860
P1433
P1476
Characterization of a preferre ...... non-homologous recombination.
@en
P2093
P2860
P304
P407
P577
1992-12-01T00:00:00Z