ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.
about
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9Regulation of TIP60 by ATF2 modulates ATM activationPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damagePurification and characterization of human DNA damage checkpoint Rad complexesCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joiningInvolvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiationThe role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotectionClamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.Rad9 modulates the P21WAF1 pathway by direct association with p53.Ataxia Telangiectasia-Mutated (ATM)Polymorphisms and Risk of Lung Cancer in a Chinese PopulationRad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibitionDNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteinsHuman RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development.Contributions of Rad9 to tumorigenesis.Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stabilityThe role of DNA exonucleases in protecting genome stability and their impact on ageing.Multiple functions of rad9 for preserving genomic integrityCandidate protein biodosimeters of human exposure to ionizing radiation.Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.Telomeres, histone code, and DNA damage response.A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation.Caspase-3-mediated cleavage of Rad9 during apoptosis.A role for the phosphorylation of hRad9 in checkpoint signaling.Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityMammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
P2860
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P2860
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
ATM-dependent phosphorylation ...... induced checkpoint activation.
@ast
ATM-dependent phosphorylation ...... induced checkpoint activation.
@en
type
label
ATM-dependent phosphorylation ...... induced checkpoint activation.
@ast
ATM-dependent phosphorylation ...... induced checkpoint activation.
@en
prefLabel
ATM-dependent phosphorylation ...... induced checkpoint activation.
@ast
ATM-dependent phosphorylation ...... induced checkpoint activation.
@en
P2093
P2860
P356
P1476
ATM-dependent phosphorylation ...... induced checkpoint activation.
@en
P2093
P2860
P304
16580-16586
P356
10.1074/JBC.M008871200
P407
P577
2001-02-06T00:00:00Z