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Design, synthesis and selection of DNA-encoded small-molecule libraries

Design, synthesis and selection of DNA-encoded small-molecule libraries

http://www.wikidata.org/entity/Q27656839

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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography Mesofluidic devices for DNA-programmed combinatorial chemistry Directed Chemical Evolution with an Outsized Genetic Code What is a "DNA-Compatible" Reaction?The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library Techniques for molecular imaging probe design Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.Interaction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment.Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction.Review article: high-throughput affinity-based technologies for small-molecule drug discovery.Targeting the undruggable proteome: the small molecules of my dreams.In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits Photoaffinity labeling of transcription factors by DNA-templated crosslinking.Encoded peptide libraries and the discovery of new cell binding ligands.A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis.Small-molecule discovery from DNA-encoded chemical libraries.The rise, fall and reinvention of combinatorial chemistry.Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.Microarray generation of thousand-member oligonucleotide libraries.20 years of DNA-encoded chemical libraries.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Highly parallel translation of DNA sequences into small molecules.Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library.Affinity-based screening techniques: their impact and benefit to increase the number of high quality leads.Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.Catalytic in vivo protein knockdown by small-molecule PROTACs.Issues in interpreting the in vivo activity of Aurora-A Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.A DNA-templated synthesis of encoded small molecules by DNA self-assembly.Drug discovery: Combichem all over again.Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.Tethered ribozyme ligation enables detection of molecular proximity in homogeneous solutions.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.Novel selection methods for DNA-encoded chemical libraries

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P2860

Design, synthesis and selection of DNA-encoded small-molecule libraries

http://www.wikidata.org/entity/Q27656839

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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type

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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Nature Chemical Biology

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Design, synthesis and selection of DNA-encoded small-molecule libraries

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P2093

Alexander L Satz

http://www.w3.org/2001/XMLSchema#string

Baoguang Zhao

http://www.w3.org/2001/XMLSchema#string

Barry A Morgan

http://www.w3.org/2001/XMLSchema#string

Cecil E Rise

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Christopher C Arico-Muendel

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Christopher P Davie

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Christopher S Kollmann

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Cynthia H Chiu

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David I Israel

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Dennis R Benjamin

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647-654

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scholarly article

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4169169

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10.1038/NCHEMBIO.211

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9

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5

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2009-08-02T00:00:00Z

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1022121817

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