Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. - Wikidata - awgldk - TriplyDB

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

http://www.wikidata.org/entity/Q33955652

about

Mammalian lipoxygenases and their biological relevance 12- and 15-lipoxygenases in adipose tissue inflammation Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2 Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies 12-lipoxygenase: a potential target for novel anti-platelet therapeutics.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors.Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.Lipids and immunoinflammatory pathways of beta cell destruction.Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes.Lipid peroxidation in cell death.NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein.Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

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P2860

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

http://www.wikidata.org/entity/Q33955652

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

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name

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@ast

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@en

type

label

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@ast

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@en

prefLabel

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@ast

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@en

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Journal of Medicinal Chemistry

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Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

@en

P2093

David J Maloney

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Ganesha Rai

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J Brian Jameson

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James M Bougie

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Jerry L Nadler

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Lena Schultz

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Michael Holinstat

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Michelle Armstrong

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Netra Joshi

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Steven Perry

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P2860

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

Discovery of a second 15S-lipoxygenase in humans

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions † ‡

Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening

Regulating leukotriene synthesis: the role of nuclear 5-lipoxygenase

Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma

5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa

Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action

12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes

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15

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David A Taylor-Fishwick

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2011-07-08T00:00:00Z

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51477602

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