Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a) - Wikidata - awgldk - TriplyDB

Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

http://www.wikidata.org/entity/Q33958412

about

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells Roles and mechanisms of cellular senescence in regulation of tissue homeostasis Tumor suppressors and cell-cycle proteins in lung cancer A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.Evidence for DNA damage checkpoint activation in barrett esophagus Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells.INK4d-deficient mice are fertile despite testicular atrophy Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function Role of p14(ARF) in replicative and induced senescence of human fibroblasts.Alterations of the p53 and pRB pathways in human astrocytoma.Increased Arf/p53 activity in stem cells, aging and cancer.p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis.Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth Analysis of cell cycle regulator proteins in non-small cell lung cancer.The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light Role of cell-cycle regulators in lung cancer.p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.Iron deprivation in cancer--potential therapeutic implications Cellular senescence: its role in tumor suppression and aging.Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.Cellular senescence: a double-edged sword in the fight against cancer.The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.Mechanism of metolachlor action due to alterations in cell cycle progression.CREG1 enhances p16(INK4a) -induced cellular senescence.The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation.The retinoblastoma protein is required for Ras-induced oncogenic transformation.Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors.Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rb-negative cells.Overall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27.Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control.Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cells.Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

http://www.wikidata.org/entity/Q33958412

description

1999 nî lūn-bûn

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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1999 թվականի մայիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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Induction of p21(WAF1/CIP1) an ...... he tumor suppressor p16(INK4a)

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P2860

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

New functional activities for the p21 family of CDK inhibitors

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Cyclin-binding motifs are essential for the function of p21CIP1

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

Growth suppression by p16ink4 requires functional retinoblastoma protein

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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10.1128/MCB.19.5.3916

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5

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19

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Wafik S. El-Deiry

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13091388

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10207115

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84249

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