Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer - Wikidata - awgldk - TriplyDB

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

http://www.wikidata.org/entity/Q33967189

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Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members Contribution of CXCL12 secretion to invasion of breast cancer cells.Copine-III interacts with ErbB2 and promotes tumor cell migration Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype Profile of neratinib and its potential in the treatment of breast cancer The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes Signaling via Shc family adapter proteins Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines Temporal regulation of EGF signalling networks by the scaffold protein Shc1 Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 ShcA signalling is essential for tumour progression in mouse models of human breast cancer Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.Oncogenes and tumor suppressor genes Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity Memo mediates ErbB2-driven cell motility.Mouse models of breast cancer metastasis.The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2 Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers.Validation: the new challenge for pathology.Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.ID genes mediate tumor reinitiation during breast cancer lung metastasis.Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis ErbB receptors and epithelial-cadherin-catenin complex in human carcinomas.Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.

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Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

http://www.wikidata.org/entity/Q33967189

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2001 nî lūn-bûn

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MCB.21.5.1540-1551.2001

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Molecular and Cellular Biology

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Grb2 and Shc adapter proteins ...... ations for human breast cancer

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B Maslikowski

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P2860

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

Protein modules and signalling networks

Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

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