DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. - Wikidata - awgldk - TriplyDB

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.

http://www.wikidata.org/entity/Q34002213

about

The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains Processing of microRNA primary transcripts requires heme in mammalian cells Fragile X-associated tremor/ataxia syndrome.Genetic variants in microRNA genes: impact on microRNA expression, function, and disease Dimerization and Heme Binding Are Conserved in Amphibian and Starfish Homologues of the microRNA Processing Protein DGCR8 The roles of microRNAs and siRNAs in mammalian spermatogenesis Molecular mechanisms of RNA interference A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting 'Black sheep' that don't leave the double-stranded RNA-binding domain fold Integrated sequence-structure motifs suffice to identify microRNA precursors.DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS MicroRNAs as potential therapeutics for treating spinal cord injury.Deformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8 From guide to target: molecular insights into eukaryotic RNA-interference machinery.Genomic imprinting, action, and interaction of maternal and fetal genomes Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8.DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.MicroRNA variants as genetic determinants of bone mass Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms.Regulation of iron homeostasis by microRNAs.Mirtrons, an emerging class of atypical miRNA.Human RNAi pathway: crosstalk with organelles and cells.CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.MicroRNA mediated regulation of immunity against gram-negative bacteria.MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level.Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.

P2860

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P2860

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.

http://www.wikidata.org/entity/Q34002213

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

DGCR8 recognizes primary trans ...... on of higher-order structures.

@ast

DGCR8 recognizes primary trans ...... on of higher-order structures.

@en

DGCR8 recognizes primary trans ...... on of higher-order structures.

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type

label

DGCR8 recognizes primary trans ...... on of higher-order structures.

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DGCR8 recognizes primary trans ...... on of higher-order structures.

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DGCR8 recognizes primary trans ...... on of higher-order structures.

@nl

prefLabel

DGCR8 recognizes primary trans ...... on of higher-order structures.

@ast

DGCR8 recognizes primary trans ...... on of higher-order structures.

@en

DGCR8 recognizes primary trans ...... on of higher-order structures.

@nl

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P2860

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DGCR8 recognizes primary trans ...... on of higher-order structures.

@en

P2093

Daniel Toso

http://www.w3.org/2001/XMLSchema#string

Feng Guo

http://www.w3.org/2001/XMLSchema#string

Ivo Atanasov

http://www.w3.org/2001/XMLSchema#string

Michael Faller

http://www.w3.org/2001/XMLSchema#string

Michio Matsunaga

http://www.w3.org/2001/XMLSchema#string

Rachel Senturia

http://www.w3.org/2001/XMLSchema#string

Yanqiu Chen

http://www.w3.org/2001/XMLSchema#string

Z Hong Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Computational identification of Drosophila microRNA genes

The nuclear RNase III Drosha initiates microRNA processing

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

The Microprocessor complex mediates the genesis of microRNAs

The Drosha-DGCR8 complex in primary microRNA processing

Crystal structure of human DGCR8 core

MicroRNA maturation: stepwise processing and subcellular localization.

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

MicroRNAs: target recognition and regulatory functions

P304

1570-1583

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scholarly article

P356

10.1261/RNA.2111310

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

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P478

16

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P577

2010-06-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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44683263

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20558544

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P932

2905756

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