Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.
about
The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle FunctionProtein-thiol oxidation and cell death: regulatory role of glutaredoxinsMitochondrial oxidative stress in aging and healthspanA strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox processGlutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.α-Ketoglutarate dehydrogenase: a mitochondrial redox sensorGlutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification.Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complexPhosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria.A mitocentric view of Alzheimer's disease suggests multi-faceted treatmentsReversible and irreversible protein glutathionylation: biological and clinical aspects.Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species.Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells.Glutathionylation in the photosynthetic model organism Chlamydomonas reinhardtii: a proteomic survey.Effects of long-term oxygen treatment on alpha-ketoglutarate dehydrogenase activity and oxidative modifications in mitochondria of the guinea pig heart.Glutaredoxin-2 is required to control proton leak through uncoupling protein-3.Protein S-glutathionylation in malaria parasites.Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.Molecular mechanisms and clinical implications of reversible protein S-glutathionylation.Prophylaxis with alpha-lipoic acid against lipopolysaccharide-induced brain injury in rats.Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions.The energy-redox axis in aging and age-related neurodegeneration.Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning.Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.Mitochondria and redox signaling in steatohepatitisLipoic acid: energy metabolism and redox regulation of transcription and cell signalingImpaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: marker or maker of the diabetic phenotype?Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer.Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy.S-glutathionylation reactions in mitochondrial function and diseaseCysteine-mediated redox signalling in the mitochondria.Metabolic control of signalling pathways and metabolic auto-regulation.Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes.Glutathionyl systems and metabolic dysfunction in obesity.Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methodsReductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase.The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity.Dihydroceramide desaturase activity is modulated by oxidative stress.
P2860
Q26774769-5902BACB-0468-436A-9004-F642867E54C2Q26852767-9DC81E3F-A8DE-4139-8122-2608C396F526Q27025099-2BE9AA17-5716-4030-8E44-C2F3B31586F1Q28390796-5C716DF2-B75B-4004-A986-8432EEBE46F0Q33652142-74EB977C-2343-4D55-9386-0751C7002548Q34024830-53213DDA-7731-4B25-9D23-8BA7B77C77EBQ34036261-4C9AD513-DF6A-4435-88E4-43DFCA18E448Q34174754-23945562-D585-4D1A-A84B-8A6E7A9A97D6Q34551789-40DEB825-2478-4781-BB0F-19821CCA4C00Q34902708-4C56D7B0-68D5-4DC5-A1F5-F6FF8436BB94Q35048314-B3CF6FC2-2ECC-4651-A9D8-12D9909E7066Q35143664-60A27949-CBC2-4A3E-84C6-AA3DDA5CFC4CQ35562774-477BC7E1-B808-450A-B47A-15ABFE495A9DQ35751691-1463F376-8298-45D6-A89A-42BA0CF1AD2DQ36464237-5501E704-F5AF-4080-AB48-1B330CDB87C6Q36708578-D91A5704-12ED-4BDA-9FA3-1B5318CD5BC3Q37064654-333A602B-E356-4294-AC99-5755B622B71CQ37170429-F0F6DC0A-5974-4D0C-AE4F-F5F9DCC8F5BEQ37262124-B7656EE5-7792-4E0A-8081-6A59AA7676A3Q37407189-27BDFADB-F41D-416C-9B22-73D5A536EC4CQ37466088-CC3C9778-D742-4417-9429-DB4815BB2830Q37493001-CB7EE33A-5AD5-42C6-9323-6C685243070DQ37588978-97FC32F3-87BA-4993-8B2E-5E91FF75DEDCQ37588981-A80A1DD2-5D1E-4F74-9606-5B16DA591E62Q37662139-3EEDC292-4BBB-4E01-A0E9-CF7CB9AD52DFQ37815476-40FB83E2-66F5-4563-B5BA-226AD696AE31Q37836402-F2EED427-D689-4694-95A9-D5C32DEF381AQ37990035-F15ECF0F-91D1-4CA4-9CE3-E8AF24B288BCQ38198977-3251F1E3-831A-4393-A30F-59DC184C9B3AQ38256907-F3F152D1-E8BD-48BB-8EC3-808EC6217995Q38276703-1463FB02-4A4D-425E-A558-9CD73F4EFD7BQ38292320-F5412C9D-DD86-485F-8B0A-FBB4AAC16C27Q38442728-02169C7A-50C3-4420-A520-8E2F81470D71Q38592775-55C63DDC-B466-4E1B-A38F-A483BBBAAC01Q38614144-054EEC93-EE0C-4A94-BF27-5C9804733509Q38680822-A3367A0D-3B8F-4037-B6C3-30EF10000D13Q38748862-EBCB999E-B4B6-4359-B487-160EFD86E50BQ38752293-E03EA81A-9DB5-4050-81A0-C7C8C5022156Q39129064-DDFB0126-8F3C-4693-8C2D-F849719404BAQ39747371-2A794C75-9F8E-4BFE-A86E-584BA108AC91
P2860
Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Reversible inhibition of alpha ...... and protection of lipoic acid.
@ast
Reversible inhibition of alpha ...... and protection of lipoic acid.
@en
Reversible inhibition of alpha ...... and protection of lipoic acid.
@nl
type
label
Reversible inhibition of alpha ...... and protection of lipoic acid.
@ast
Reversible inhibition of alpha ...... and protection of lipoic acid.
@en
Reversible inhibition of alpha ...... and protection of lipoic acid.
@nl
prefLabel
Reversible inhibition of alpha ...... and protection of lipoic acid.
@ast
Reversible inhibition of alpha ...... and protection of lipoic acid.
@en
Reversible inhibition of alpha ...... and protection of lipoic acid.
@nl
P356
P1433
P1476
Reversible inhibition of alpha ...... and protection of lipoic acid.
@en
P2093
Kenneth M Humphries
Milana A B Applegate
P304
P356
10.1021/BI7017464
P407
P577
2007-12-15T00:00:00Z