Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.
about
Unveiling the intracellular survival gene kit of trypanosomatid parasitesInduction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolismDepletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania majorDiscovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate libraryEvolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion.Use of click chemistry to define the substrate specificity of Leishmania beta-1,2-mannosyltransferases.Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical librarySecretory pathway of trypanosomatid parasites.The N-terminal domain and glycosomal localization of Leishmania initial acyltransferase LmDAT are important for lipophosphoglycan synthesisLeishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viabilityIdentification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategiesGlycoinositolphospholipids from Leishmania braziliensis and L. infantum: modulation of innate immune system and variations in carbohydrate structureVirulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphataseCharacterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogsLeishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surfaceLeishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?Dissecting Leishmania infantum Energy Metabolism - A Systems Perspective.Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression.The LPG1 gene family of Leishmania major.Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery.Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates.In-silico Leishmania target selectivity of antiparasitic terpenoids.Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence.Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei.Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites.Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana.Early CD44(hi)CD4+ and CD44(hi)CD8+ T cell numbers and the absence of mannose-rich glycoconjugates determine the protective outcome of anti-leishmanial immunity.The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei.A Temperature-sensitive mutation in the Arabidopsis thaliana phosphomannomutase gene disrupts protein glycosylation and triggers cell death.Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities.Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host.Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana.
P2860
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P2860
Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@ast
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@en
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@nl
type
label
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@ast
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@en
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@nl
prefLabel
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@ast
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@en
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@nl
P2093
P2860
P921
P1476
Glycosylation defects and viru ...... ynthase gene deletion mutants.
@en
P2093
P2860
P304
P356
10.1128/MCB.21.23.8168-8183.2001
P407
P577
2001-12-01T00:00:00Z