Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration - Wikidata - awgldk - TriplyDB

Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration

Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration

http://www.wikidata.org/entity/Q34017086

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NMDA Receptor Function During Senescence: Implication on Cognitive Performance Glial cells in (patho)physiology The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.Acute D-serine treatment produces antidepressant-like effects in rodents Cell-type specific mechanisms of D-serine uptake and release in the brain The role of D-amino acids in amyotrophic lateral sclerosis pathogenesis: a review.Nicotine uses neuron-glia communication to enhance hippocampal synaptic transmission and long-term memory.Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.Sweet taste receptor signaling network: possible implication for cognitive functioning.Astrocytes release D-serine by a large vesicle D-serine uptake and release in PC-12 cells measured by chiral microchip electrophoresis-mass spectrometry.Neuronal D-serine regulates dendritic architecture in the somatosensory cortex DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells.Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase.Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons D-serine as a gliotransmitter and its roles in brain development and disease.Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.Is astrocyte calcium signaling relevant for synaptic plasticity?Exocytosis in astrocytes: transmitter release and membrane signal regulation.Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes.Serine racemase: an unconventional enzyme for an unconventional transmitter.Amperometric microbiosensor as an alternative tool for investigation of D-serine in brain.D-Amino acids in brain neurotransmission and synaptic plasticity.Astroglial amino acid-based transmitter receptors.NMDA receptor activation: two targets for two co-agonists.Serine racemase as a prime target for age-related memory deficits.Perisynaptic astroglial processes: dynamic processors of neuronal information.Astrocyte sodium signaling and the regulation of neurotransmission.D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.Role of Astrocytes in Central Respiratory Chemoreception.The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis.The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.An overview on D-amino acids.Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain.In vivo D-serine hetero-exchange through alanine-serine-cysteine (ASC) transporters detected by microelectrode biosensors.AMPA receptor mediated D-serine release from retinal glial cells.

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Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration

http://www.wikidata.org/entity/Q34017086

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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Neuronal release of D-serine: ...... ellular D-serine concentration

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Chanda M C Klinker

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Dina Rosenberg

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Elena Kartvelishvily

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Maria Shleper

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Michael T Bowser

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P2860

Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids

Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

Glia-derived D-serine controls NMDA receptor activity and synaptic memory

High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices

Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei

Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

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2951-2961

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10.1096/FJ.09-147967

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2909281

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