Deficient Smad7 expression: a putative molecular defect in scleroderma. - Wikidata - awgldk - TriplyDB

Deficient Smad7 expression: a putative molecular defect in scleroderma.

Deficient Smad7 expression: a putative molecular defect in scleroderma.

http://www.wikidata.org/entity/Q34021184

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Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling Smad7 is required for the development and function of the heart Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55 Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts Paclitaxel modulates TGFbeta signaling in scleroderma skin grafts in immunodeficient mice.Epithelial-mesenchymal transition in tissue repair and fibrosis Calciphylaxis and metastatic calcification associated with nephrogenic fibrosing dermopathy.Systemic sclerosis: current concepts in pathogenesis and therapeutic aspects of dermatological manifestations.Effects of Chinese traditional compound, JinSanE, on expression of TGF-beta1 and TGF-beta1 type II receptor mRNA, Smad3 and Smad7 on experimental hepatic fibrosis in vivo.Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Transforming growth factor-beta and fibrosis Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.Bone Morphogenetic Protein (BMP) signaling in development and human diseases Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.Transforming growth factor-β in graft vessels: histology and immunohistochemistry.Ubiquitin-dependent regulation of TGFbeta signaling in cancer Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma.Plasminogen activator/plasmin system: a major player in wound healing?The Active Form of Vitamin D Transcriptionally Represses Smad7 Signaling and Activates Extracellular Signal-regulated Kinase (ERK) to Inhibit the Differentiation of a Inflammatory T Helper Cell Subset and Suppress Experimental Autoimmune Encephalomy Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture.Systemic sclerosis: a prototypic multisystem fibrotic disorder.Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin.Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats.Smad3 as a mediator of the fibrotic response.Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration.Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.TGF-beta signal transduction in oro-facial health and non-malignant disease (part I).Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective.Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts.Scar wars: is TGFbeta the phantom menace in scleroderma?Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse.Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model.Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension.MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells.

P2860

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P2860

Deficient Smad7 expression: a putative molecular defect in scleroderma.

http://www.wikidata.org/entity/Q34021184

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@ast

Deficient Smad7 expression: a putative molecular defect in scleroderma.

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Deficient Smad7 expression: a putative molecular defect in scleroderma.

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type

label

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@ast

Deficient Smad7 expression: a putative molecular defect in scleroderma.

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Deficient Smad7 expression: a putative molecular defect in scleroderma.

@nl

prefLabel

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@ast

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@en

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Deficient Smad7 expression: a putative molecular defect in scleroderma.

@en

P2093

Barbara White

http://www.w3.org/2001/XMLSchema#string

Chunming Dong

http://www.w3.org/2001/XMLSchema#string

Fredrick M Wigley

http://www.w3.org/2001/XMLSchema#string

Pascal J Goldschmidt-Clermont

http://www.w3.org/2001/XMLSchema#string

Peter ten Dijke

http://www.w3.org/2001/XMLSchema#string

Rene J Alvarez

http://www.w3.org/2001/XMLSchema#string

Shoukang Zhu

http://www.w3.org/2001/XMLSchema#string

Tao Wang

http://www.w3.org/2001/XMLSchema#string

Woohyun Yoon

http://www.w3.org/2001/XMLSchema#string

Zhiru Li

http://www.w3.org/2001/XMLSchema#string

P2860

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

Smads: transcriptional activators of TGF-beta responses

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

Smads as transcriptional co-modulators.

P304

3908-3913

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scholarly article

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10.1073/PNAS.062010399

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P433

6

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99

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2002-03-01T00:00:00Z

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11460479

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11904440

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122622

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