PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. - Wikidata - awgldk - TriplyDB

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

http://www.wikidata.org/entity/Q34024253

about

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death Endoplasmic reticulum stress and type 2 diabetes Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus INS-gene mutations: from genetics and beta cell biology to clinical disease Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology Sox17 regulates insulin secretion in the normal and pathologic mouse β cell Many faces of monogenic diabetes Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport Hyperthermia induces the ER stress pathway.Wolcott-Rallison syndrome Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Frequency and spectrum of Wolcott-Rallison syndrome in Saudi Arabia: a systematic review.Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.In vivo misfolding of proinsulin below the threshold of frank diabetes.Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density.PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.Dominant protein interactions that influence the pathogenesis of conformational diseases.Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.PERK in beta cell biology and insulin biogenesis.Endoplasmic reticulum stress and pancreatic β-cell death.New insights into translational regulation in the endoplasmic reticulum unfolded protein response.The role of the unfolded protein response in diabetes mellitus.Role of the unfolded protein response in β cell compensation and failure during diabetes.Insulin gene mutations and diabetes Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content.

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P2860

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

http://www.wikidata.org/entity/Q34024253

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

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PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

@en

PERK

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type

label

PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

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PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

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PERK

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prefLabel

PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

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PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

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PERK

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P1476

PERK (EIF2AK3) regulates proin ...... trol in the secretory pathway.

@en

P2093

Barbara McGrath

http://www.w3.org/2001/XMLSchema#string

Sounak Gupta

http://www.w3.org/2001/XMLSchema#string

P2860

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

Maintenance of Golgi structure and function depends on the integrity of ER export

A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

ERAD: the long road to destruction

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

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1937-1947

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scholarly article

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10.2337/DB09-1064

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P433

8

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59

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Douglas R Cavener

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2010-06-08T00:00:00Z

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44656472

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20530744

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P921

quality control

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2911049

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