Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations
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Aspartate 112 is the selectivity filter of the human voltage-gated proton channelVoltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domainsTherapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoverySynergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel InhibitorsVoltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) familyDisrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysisTracking S4 movement by gating pore currents in the bacterial sodium channel NaChBac.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.High guanidinium permeability reveals dehydration-dependent ion selectivity in the plasmodial surface anion channel.Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotoniaRecent advances in the pathogenesis and drug action in periodic paralyses and related channelopathies.Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.The pore of the voltage-gated proton channelStructural basis for gating charge movement in the voltage sensor of a sodium channelGating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Voltage Sensing in Membranes: From Macroscopic Currents to Molecular MotionsGating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.Pathophysiological role of omega pore current in channelopathiesFinding Channels.A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.Transient compartment-like syndrome and normokalaemic periodic paralysis due to a Ca(v)1.1 mutation.NaV1.4 mutations cause hypokalaemic periodic paralysis by disrupting IIIS4 movement during recovery.Novel insights into the pathomechanisms of skeletal muscle channelopathies.Neurological perspectives on voltage-gated sodium channels.Biophysics, pathophysiology, and pharmacology of ion channel gating pores.Mutational consequences of aberrant ion channels in neurological disorders.Genotype phenotype associations across the voltage-gated sodium channel family.Molecular biology and biophysical properties of ion channel gating pores.Elevated resting H(+) current in the R1239H type 1 Hypokalemic Periodic Paralysis mutated Ca(2+) channel.Grand challenge for ion channels: an underexploited resource for therapeutics.Atomistic Modeling of Ion Conduction through the Voltage-Sensing Domain of the Shaker K+ Ion Channel.Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels.Spider toxin inhibits gating pore currents underlying periodic paralysis.Hypokalaemic periodic paralysis and myotonia in a patient with homozygous mutation p.R1451L in NaV1.4.A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating PoresGating Pore Currents in Sodium Channels
P2860
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P2860
Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ion permeation and block of th ...... c periodic paralysis mutations
@ast
Ion permeation and block of th ...... c periodic paralysis mutations
@en
Ion permeation and block of th ...... c periodic paralysis mutations
@nl
type
label
Ion permeation and block of th ...... c periodic paralysis mutations
@ast
Ion permeation and block of th ...... c periodic paralysis mutations
@en
Ion permeation and block of th ...... c periodic paralysis mutations
@nl
prefLabel
Ion permeation and block of th ...... c periodic paralysis mutations
@ast
Ion permeation and block of th ...... c periodic paralysis mutations
@en
Ion permeation and block of th ...... c periodic paralysis mutations
@nl
P2093
P2860
P356
P1476
Ion permeation and block of th ...... c periodic paralysis mutations
@en
P2093
Stanislav Sokolov
Todd Scheuer
William A Catterall
P2860
P304
P356
10.1085/JGP.201010414
P577
2010-08-01T00:00:00Z