C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity - Wikidata - awgldk - TriplyDB

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

http://www.wikidata.org/entity/Q34035872

about

Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake AMPK in the brain: its roles in energy balance and neuroprotection Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase Fatty acid metabolism, the central nervous system, and feeding Structure and function of carnitine acyltransferases Role of fatty-acid synthesis in dendritic cell generation and function Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity Parameter trajectory analysis to identify treatment effects of pharmacological interventions Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation Luminal fructose inhibits rat intestinal sodium-phosphate cotransporter gene expression and phosphate uptake Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice.[Physiological mechanisms in the development of adiposity].A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.A requirement for fatty acid oxidation in the hormone-induced meiotic maturation of mouse oocytes.The lipoprivic control of feeding is governed by fat metabolism, not by leptin or adipose depletion.The search for new ways to treat obesity.Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle.The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice.α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase.Current and investigational antiobesity agents and obesity therapeutic treatment targets.Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism.Inhibition of fatty acid metabolism reduces human myeloma cells proliferation.Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats.Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species.Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome.Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha.Efficacy of massage therapy on pain and dysfunction in patients with neck pain: a systematic review and meta-analysis.Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis through alleviating Akt-mediated myocardial autophagy suppression in high-fat diet-induced obesity.Metabolic alterations and targeted therapies in prostate cancer.Fatty acid synthase as a potential therapeutic target in cancer.Lipid metabolic enzymes: emerging drug targets for the treatment of obesity.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.Stearoyl-CoA desaturase as a new drug target for obesity treatment.

P2860

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P2860

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

http://www.wikidata.org/entity/Q34035872

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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type

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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C75 increases peripheral energ ...... dation in diet-induced obesity

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Proceedings of the National Academy of Sciences of the United States of America

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C75 increases peripheral energ ...... dation in diet-induced obesity

@en

P2093

Francis P Kuhajda

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Gabriele V Ronnett

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Jagan N Thupari

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Leslie E Landree

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P2860

The first 28 N-terminal amino acid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl CoA sensitivity and high-affinity binding

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.

Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice.

Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.

Synthesis and antitumor activity of an inhibitor of fatty acid synthase.

Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat

Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.

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9498-9502

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scholarly article

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10.1073/PNAS.132128899

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14

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99

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2002-06-11T00:00:00Z

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11313103

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12060712

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123169

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