Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients - Wikidata - awgldk - TriplyDB

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

http://www.wikidata.org/entity/Q34037076

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Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier.C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence.Bromodomain inhibitors regulate the C9ORF72 locus in ALS Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration.C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation.Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells.Opening up the DNA methylome of dementia Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease.Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions.ALS and FTD: an epigenetic perspective.R Loops and Links to Human Disease.Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity.The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter.Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients.Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis.The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.Impact of Lactational Exposure to Polychlorinated Biphenyl Causes Epigenetic Modification and Impairs Sertoli Cells Functional Regulators in F1 Progeny.Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.

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Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

http://www.wikidata.org/entity/Q34037076

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@ast

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@en

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@nl

type

label

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@ast

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@en

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@nl

prefLabel

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@ast

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@en

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@nl

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P356

J.BRAINRES.2014.02.015

P1433

P1476

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

@en

P2093

Tania F Gendron

http://www.w3.org/2001/XMLSchema#string

Veronique V Belzil

http://www.w3.org/2001/XMLSchema#string

P2860

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

Oxidative stress and epigenetic regulation in ageing and age-related diseases

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

The involvement of the cerebellum in amyotrophic lateral sclerosis.

Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.

Epigenetic regulation of motor neuron cell death through DNA methylation.

Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.

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15-21

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scholarly article

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10.1016/J.BRAINRES.2014.02.015

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P478

1584

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Dennis W. Dickson

Melissa E. Murray

Leonard Petrucelli

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2014-02-12T00:00:00Z

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260167064

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24530272

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amyotrophic lateral sclerosis

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4130919

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