Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
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E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and DiseaseTumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents.T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signalingRegulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.At the crossroads: diverse roles of early thymocyte transcriptional regulators.A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signalingNotch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.Wnt signaling in leukemias and myeloma: T-cell factors are in control.Transcription factors and target genes of pre-TCR signaling.E2A proteins enforce a proliferation checkpoint in developing thymocytesp53 regulates thymic Notch1 activation.Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphomaPlacing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
P2860
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P2860
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
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2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2002 թվականի օգոստոսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
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Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@en
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
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label
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@ast
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@en
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@nl
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Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@ast
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@en
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@nl
P2860
P356
P1476
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
@en
P2093
Cornelis Murre
Isaac Engel
P2860
P304
11322-11327
P356
10.1073/PNAS.162373999
P407
P577
2002-08-09T00:00:00Z