Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo - Wikidata - awgldk - TriplyDB

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

http://www.wikidata.org/entity/Q34044164

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Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene Huntingtin promotes cell survival by preventing Pak2 cleavage Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity Huntingtin in health and disease Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor Neural and mesenchymal stem cells in animal models of Huntington's disease: past experiences and future challenges Iron dysregulation in Huntington's disease Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 PAK in Alzheimer disease, Huntington disease and X-linked mental retardation Normal huntingtin function: an alternative approach to Huntington's disease Huntingtin inhibits caspase-3 activation The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro.A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesi Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity Systemic delivery of P42 peptide: a new weapon to fight Huntington's disease.Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.Therapeutic approaches to preventing cell death in Huntington disease Caspases in Huntington's disease.Transgenic animal models of neurodegeneration based on human genetic studies.Clinical and research advances in Huntington's disease.Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington's disease.The paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration.Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity Membrane trafficking in neuronal maintenance and degeneration.The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.Mutant huntingtin and mitochondrial dysfunction.Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain.Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.Cytotoxicity of mutant huntingtin fragment in yeast can be modulated by the expression level of wild type huntingtin fragment.

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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

http://www.wikidata.org/entity/Q34044164

description

2000 nî lūn-bûn

@nan

2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年学术文章

@wuu

2000年学术文章

@zh-cn

2000年学术文章

@zh-hans

2000年学术文章

@zh-my

2000年学术文章

@zh-sg

2000年學術文章

@yue

name

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@ast

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@en

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@nl

type

label

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@ast

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@en

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@nl

prefLabel

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@ast

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@en

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@nl

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American Journal of Human Genetics

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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

@en

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A W Vogl

http://www.w3.org/2001/XMLSchema#string

B R Leavitt

http://www.w3.org/2001/XMLSchema#string

G H Kimel

http://www.w3.org/2001/XMLSchema#string

J A Guttman

http://www.w3.org/2001/XMLSchema#string

J G Hodgson

http://www.w3.org/2001/XMLSchema#string

M R Hayden

http://www.w3.org/2001/XMLSchema#string

R Singaraja

http://www.w3.org/2001/XMLSchema#string

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A huntingtin-associated protein enriched in brain with implications for pathology

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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313-324

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scholarly article

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10.1086/318207

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2

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68

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2000-12-20T00:00:00Z

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12196313

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11133364

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1235265

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