PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
about
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesThe tripartite motif family identifies cell compartments.Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion proteinLeukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodiesCharacterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein familyIn vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PMLThe solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PMLCellular localization, expression, and structure of the nuclear dot protein 52PML, a growth suppressor disrupted in acute promyelocytic leukemiaThe promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma proteinResistance to virus infection conferred by the interferon-induced promyelocytic leukemia proteinMLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein functionSMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemiaPIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemiaRetinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteinsDNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemiaArsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemiaThe N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogeneCCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways.Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.A PMLRARalpha transgene initiates murine acute promyelocytic leukemiaIn vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.Role of promyelocytic leukemia (PML) protein in tumor suppressionReciprocal Control of Osteogenic and Adipogenic Differentiation by ERK/MAP Kinase Phosphorylation of Runx2 and PPARγ Transcription Factors.Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic LeukemiaAcute leukemia with promyelocytic features in PML/RARalpha transgenic mice.A systems approach implicates nuclear receptor targeting in the Atp7b(-/-) mouse model of Wilson's disease.Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha.Genome-wide functions of PML-RARα in acute promyelocytic leukaemiaEffects of PPARγ Ligands on Leukemia.
P2860
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P2860
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
description
1993 nî lūn-bûn
@nan
1993 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@ast
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@en
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@nl
type
label
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@ast
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@en
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@nl
prefLabel
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@ast
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@en
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@nl
P2093
P2860
P1433
P1476
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1993.TB05986.X
P407
P577
1993-08-01T00:00:00Z