15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. - Wikidata - awgldk - TriplyDB

15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.

15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.

http://www.wikidata.org/entity/Q34063810

about

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells The organization and consequences of eicosanoid signaling Role of prostaglandins in neuroinflammatory and neurodegenerative diseases New targets for the antitumor activity of gambogic acid in hematologic malignancies The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia T-REX on-demand redox targeting in live cells.Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma.Increased expression ratio of Bcl-2/Bax is associated with crocin-mediated apoptosis in bovine aortic endothelial cells.Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation.Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential.Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function.Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity.Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2.Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death.The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator.Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.Cyclooxygenase-2 enhances antimicrobial peptide expression and killing of Staphylococcus aureus.Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.Molecular biological approaches to neurological disorders including knockout and transgenic mouse models.Isoprostane generation and function.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases.The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest.Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for hypoxic ischemic injury Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.Mitochondrial protein targets of thiol-reactive electrophiles 15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification.Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.

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15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.

http://www.wikidata.org/entity/Q34063810

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

@zh-hk

2002年論文

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2002年論文

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2002年论文

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name

15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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type

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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prefLabel

15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

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Proceedings of the National Academy of Sciences of the United States of America

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15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.

@en

P2093

Koji Uchida

http://www.w3.org/2001/XMLSchema#string

Makio Kobayashi

http://www.w3.org/2001/XMLSchema#string

Makoto Iwata

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Mitsuhiro Kondo

http://www.w3.org/2001/XMLSchema#string

Noriko Noguchi

http://www.w3.org/2001/XMLSchema#string

Noriyuki Shibata

http://www.w3.org/2001/XMLSchema#string

Shoichi Sasaki

http://www.w3.org/2001/XMLSchema#string

Takahiro Shibata

http://www.w3.org/2001/XMLSchema#string

Takeshi Kumagai

http://www.w3.org/2001/XMLSchema#string

Toshihiko Osawa

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

A model for p53-induced apoptosis

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

4-hydroxy-2-nonenal, the end product of lipid peroxidation, is a specific inducer of cyclooxygenase-2 gene expression

Apoptosis in the pathogenesis and treatment of disease

p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

p53 and the CNS: tumors and developmental abnormalities.

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.

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7367-7372

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scholarly article

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10.1073/PNAS.112212599

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11

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99

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2002-05-01T00:00:00Z

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11340797

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12032289

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15-deoxy-δ12,14-prostaglandin j2

P932

124237

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