Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. - Wikidata - awgldk - TriplyDB

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

http://www.wikidata.org/entity/Q34074630

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Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products The emerging use of zebrafish to model metabolic disease Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation Metabolic insights from zebrafish genetics, physiology, and chemical biology Larval zebrafish model for FDA-approved drug repositioning for tobacco dependence treatment Semi-automated imaging of tissue-specific fluorescence in zebrafish embryos.Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.15 years of zebrafish chemical screening Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.Evaluating human cancer cell metastasis in zebrafish.Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.In vitro screening for drug repositioning.Differential levels of Neurod establish zebrafish endocrine pancreas cell fates.Chemical genetics and regeneration.First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.Small zebrafish in a big chemical pond.Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway.Chemical screening in zebrafish for novel biological and therapeutic discovery.Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.Zebrafish models of human liver development and disease Imaging beta cell regeneration and interactions with islet vasculature in transparent adult zebrafish.Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio.Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish.Advances in zebrafish chemical screening technologies.Use of zebrafish embryos for small molecule screening related to cancer.Targeting the pancreatic β-cell to treat diabetes.Zebrafish as tools for drug discovery.Centroacinar cells: At the center of pancreas regeneration.LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development.ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates.Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation.An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model.Redox stress and signaling during vertebrate embryonic development: Regulation and responses.Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio).In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis.

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Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

http://www.wikidata.org/entity/Q34074630

description

2011 nî lūn-bûn

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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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name

Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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type

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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Proceedings of the National Academy of Sciences of the United States of America

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Chemical screen identifies FDA ...... tic endocrine differentiation.

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P2093

Anthony A Ferrante

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Joong Sup Shim

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Jun O Liu

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Meritxell Rovira

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Michael J Parsons

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Shamila Yusuff

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Wei Huang

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P2860

IMP dehydrogenase: structure, mechanism, and inhibition.

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts

Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells.

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target.

A clinical drug library screen identifies astemizole as an antimalarial agent.

Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions.

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

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19264-19269

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10.1073/PNAS.1113081108

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48

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51798938

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22084084

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