Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.
about
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell deathThe structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice modelConformational analysis of misfolded protein aggregation by FRET and live-cell imaging techniquesElongation kinetics of polyglutamine peptide fibrils: a quartz crystal microbalance with dissipation study.Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assayTiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's diseasePolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.Protein disorder in the human diseasome: unfoldomics of human genetic diseases.A new cloning strategy for generating multiple repeats of a repetitive polypeptide based on non-template PCR.Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicityThe stability and dynamics of the human calcitonin amyloid peptide DFNKFElectroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.Side-chain interactions determine amyloid formation by model polyglutamine peptides in molecular dynamics simulations.Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds.Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog.Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases.Therapeutic strategies for human amyloid diseases.A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila.Location trumps length: polyglutamine-mediated changes in folding and aggregation of a host proteinTargeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases.Aggregation kinetics of interrupted polyglutamine peptidesPolyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopyPolyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophyQuantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theories.Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.Sequestration of Sup35 by aggregates of huntingtin fragments causes toxicity of [PSI+] yeast.The structural impact of a polyglutamine tract is location-dependentCarbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.Amyloidogenesis of natively unfolded proteins.Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.Pathology and function of nuclear amyloid. Protein homeostasis matters.Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro ModelCounting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage.Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
P2860
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P2860
Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Protein aggregation and pathog ...... : mechanisms and correlations.
@ast
Protein aggregation and pathog ...... : mechanisms and correlations.
@en
Protein aggregation and pathog ...... : mechanisms and correlations.
@nl
type
label
Protein aggregation and pathog ...... : mechanisms and correlations.
@ast
Protein aggregation and pathog ...... : mechanisms and correlations.
@en
Protein aggregation and pathog ...... : mechanisms and correlations.
@nl
prefLabel
Protein aggregation and pathog ...... : mechanisms and correlations.
@ast
Protein aggregation and pathog ...... : mechanisms and correlations.
@en
Protein aggregation and pathog ...... : mechanisms and correlations.
@nl
P2860
P356
P1433
P1476
Protein aggregation and pathog ...... : mechanisms and correlations.
@en
P2093
P2860
P304
P356
10.1515/BC.2000.114
P577
2000-09-01T00:00:00Z