The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily.
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Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicologyKinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family membersCrystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanismsA Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic PathwayMIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrationsKinetic, Mutational, and Structural Analysis of Malonate Semialdehyde Decarboxylase from Coryneform Bacterium Strain FG41: Mechanistic Implications for the Decarboxylase and Hydratase ActivitiesEvidence for the formation of an enamine species during aldol and Michael-type addition reactions promiscuously catalyzed by 4-oxalocrotonate tautomeraseMolecular signatures-based prediction of enzyme promiscuity.Identification and characterization of new family members in the tautomerase superfamily: analysis and implicationsProduction of proteasome inhibitor syringolin A by the endophyte Rhizobium sp. strain AP16.Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease.Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory interventionReaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine.Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations.Reactions of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue, with Acetylene and Allene Substrates: Evidence for a Hydration-Dependent Decarboxylation.Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes.A pre-steady state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild-type enzymeA mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase.A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase.Enzyme (re)design: lessons from natural evolution and computation.Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications.Recent advances in the study of enzyme promiscuity in the tautomerase superfamily.Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.Resolution of the uncertainty in the kinetic mechanism for the trans-3-Chloroacrylic acid dehalogenase-catalyzed reaction.Demethionylation of Pro-1 variants of 4-oxalocrotonate tautomerase in Escherichia coli by co-expression with an engineered methionine aminopeptidase.A residue outside the active site CXXC motif regulates the catalytic efficiency of Glutaredoxin 3.Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function.Unusual C=C bond isomerization of an α,β-unsaturated γ-butyrolactone catalysed by flavoproteins from the old yellow enzyme family.Promiscuous catalysis of asymmetric Michael-type additions of linear aldehydes to β-nitrostyrene by the proline-based enzyme 4-oxalocrotonate tautomerase.A global view of structure-function relationships in the tautomerase superfamily.Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily.Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase.Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes.
P2860
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P2860
The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The chemical versatility of th ...... n the tautomerase superfamily.
@ast
The chemical versatility of th ...... n the tautomerase superfamily.
@en
The chemical versatility of th ...... n the tautomerase superfamily.
@nl
type
label
The chemical versatility of th ...... n the tautomerase superfamily.
@ast
The chemical versatility of th ...... n the tautomerase superfamily.
@en
The chemical versatility of th ...... n the tautomerase superfamily.
@nl
prefLabel
The chemical versatility of th ...... n the tautomerase superfamily.
@ast
The chemical versatility of th ...... n the tautomerase superfamily.
@en
The chemical versatility of th ...... n the tautomerase superfamily.
@nl
P2093
P2860
P1476
The chemical versatility of th ...... n the tautomerase superfamily.
@en
P2093
C P Whitman
G J Poelarends
V Puthan Veetil
P2860
P2888
P304
P356
10.1007/S00018-008-8285-X
P577
2008-11-01T00:00:00Z