Enzyme (re)design: lessons from natural evolution and computation.
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Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triadExpanding P450 catalytic reaction space through evolution and engineeringAllosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulationsDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeDirected Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase SuperfamilyX-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavengerComputational design of an endo-1,4- -xylanase ligand binding siteMechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid ReceptorPhosphodeoxyribosyltransferases, Designed Enzymes for Deoxyribonucleotides SynthesisComputational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysisEnzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimesAnalyzing protein structure and function using ancestral gene reconstructionAchievements and challenges in structural bioinformatics and computational biophysicsFree energies for coarse-grained proteins by integrating multibody statistical contact potentials with entropies from elastic network models.The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution.Betaalpha-hairpin clamps brace betaalphabeta modules and can make substantive contributions to the stability of TIM barrel proteins.Engineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy.Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase.Site-saturation mutagenesis: a powerful tool for structure-based design of combinatorial mutation libraries.An enzymatic platform for the synthesis of isoprenoid precursors.Increasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis toward mandelonitrile by copying active site residues from an esterase that accepts aromatic esters.Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approachComputer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein EngineeringResilience of biochemical activity in protein domains in the face of structural divergence.Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.Molecular dynamics simulation and conformational analysis of some catalytically active peptides.An assessment of catalytic residue 3D ensembles for the prediction of enzyme functionConstructing de novo biosynthetic pathways for chemical synthesis inside living cells.The Structure-Function Linkage DatabaseEditor's choice: Crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks.Multifunctional enzymes in archaea: promiscuity and moonlight.Computational enzyme design.Protein design in systems metabolic engineering for industrial strain development.Computational Enzyme Design: Advances, hurdles and possible ways forwardRecent advances in rational approaches for enzyme engineering.Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity.The nature of chemical innovation: new enzymes by evolution.Computational tools for the evaluation of laboratory-engineered biocatalysts.Molecular mechanical properties of short-sequence peptide enzyme mimics.Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.
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P2860
Enzyme (re)design: lessons from natural evolution and computation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Enzyme (re)design: lessons from natural evolution and computation.
@en
Enzyme
@nl
type
label
Enzyme (re)design: lessons from natural evolution and computation.
@en
Enzyme
@nl
prefLabel
Enzyme (re)design: lessons from natural evolution and computation.
@en
Enzyme
@nl
P2860
P1476
Enzyme (re)design: lessons from natural evolution and computation.
@en
P2093
John A Gerlt
P2860
P356
10.1016/J.CBPA.2009.01.014
P577
2009-02-23T00:00:00Z