Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.
about
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionCell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damageHuman Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpointCharacterization of functional domains in human ClaspinMrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpointClaspin promotes normal replication fork rates in human cellsDNA polymerase ε and its roles in genome stabilityThe high fidelity and unique error signature of human DNA polymerase epsilonRad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forksDrf1-dependent kinase interacts with Claspin through a conserved protein motif.A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombeIKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.The structural determinants of checkpoint activationSite-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresTethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin.The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointDNA polymerase epsilon: a polymerase of unusual size (and complexity).The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Molecular mechanisms of DNA replication checkpoint activationCRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint functionMrc1/Claspin: a new role for regulation of origin firing.Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.Claspin recruits Cdc7 kinase for initiation of DNA replication in human cellsClaspin and Chk1 regulate replication fork stability by different mechanisms.The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.Activation of CHEK1 at resected DNA DSBsEfficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions.USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.
P2860
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P2860
Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Roles of replication fork-inte ...... plication checkpoint response.
@ast
Roles of replication fork-inte ...... plication checkpoint response.
@en
Roles of replication fork-inte ...... plication checkpoint response.
@nl
type
label
Roles of replication fork-inte ...... plication checkpoint response.
@ast
Roles of replication fork-inte ...... plication checkpoint response.
@en
Roles of replication fork-inte ...... plication checkpoint response.
@nl
prefLabel
Roles of replication fork-inte ...... plication checkpoint response.
@ast
Roles of replication fork-inte ...... plication checkpoint response.
@en
Roles of replication fork-inte ...... plication checkpoint response.
@nl
P2093
P2860
P356
P1476
Roles of replication fork-inte ...... plication checkpoint response.
@en
P2093
Andrej Shevchenko
Anna Shevchenko
Daniel A Gold
William G Dunphy
P2860
P304
P356
10.1091/MBC.E05-07-0671
P577
2005-09-07T00:00:00Z