Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. - Wikidata - awgldk - TriplyDB

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

http://www.wikidata.org/entity/Q46847087

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Mechanism of cancer cell death induced by depletion of an essential replication regulator Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195 A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Regulation and roles of Cdc7 kinase under replication stress.The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.Chk1 promotes replication fork progression by controlling replication initiation.Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells.Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress Mrc1/Claspin: a new role for regulation of origin firing.Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast.Molecular architecture of the DNA replication origin activation checkpoint.Roles of human AND-1 in chromosome transactions in S phase ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7.p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.Replication checkpoint: tuning and coordination of replication forks in s phase.Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.Claspin and Chk1 regulate replication fork stability by different mechanisms.Drug design with Cdc7 kinase: a potential novel cancer therapy target.Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions.A novel p53-Cdc7 link induced by genotoxic stress.USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

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P2860

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

http://www.wikidata.org/entity/Q46847087

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@en

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@nl

type

label

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@en

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@nl

prefLabel

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@en

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

@nl

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P1476

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

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P2093

H Masai

http://www.w3.org/2001/XMLSchema#string

J M Kim

http://www.w3.org/2001/XMLSchema#string

M Yamada

http://www.w3.org/2001/XMLSchema#string

N Kakusho

http://www.w3.org/2001/XMLSchema#string

N Takemoto

http://www.w3.org/2001/XMLSchema#string

Y Kanoh

http://www.w3.org/2001/XMLSchema#string

P2860

A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint

A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases

An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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3475-3482

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10.1038/SJ.ONC.1210994

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24

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27

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2007-12-17T00:00:00Z

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5765045

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18084324

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P921

phosphorylation