Pathological alpha-synuclein propagates through neural networks - Wikidata - awgldk - TriplyDB

Pathological alpha-synuclein propagates through neural networks

Pathological alpha-synuclein propagates through neural networks

http://www.wikidata.org/entity/Q34100338

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Neurodegenerative diseases: expanding the prion concept Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Parkinson's disease: animal models and dopaminergic cell vulnerability Alpha-synuclein spreading in Parkinson's disease Whole-brain 3D mapping of human neural transplant innervation.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.The Interplay between Alpha-Synuclein Clearance and Spreading Progression of Seed-Induced Aβ Deposition within the Limbic Connectome Chronic exposure to cerebrospinal fluid of multiple system atrophy in neuroblastoma and glioblastoma cells induces cytotoxicity via ER stress and autophagy activation Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates Transport of cargo from periphery to brain by circulating monocytes.Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases.Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans.Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Propagation of pathological α-synuclein in marmoset brain.Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.Alpha-synuclein propagation: New insights from animal models.The cellular prion protein (PrPC) as neuronal receptor for α-synuclein.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Synaptic failure and α-synuclein.Targeting α-synuclein: Therapeutic options.The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.Multiple system atrophy: pathogenic mechanisms and biomarkers.α-Synuclein: Experimental Pathology.Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

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Pathological alpha-synuclein propagates through neural networks

http://www.wikidata.org/entity/Q34100338

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2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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type

label

Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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prefLabel

Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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Pathological alpha-synuclein propagates through neural networks

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Acta neuropathologica communications

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Pathological alpha-synuclein propagates through neural networks

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Aki Shimozawa

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Haruhiko Akiyama

http://www.w3.org/2001/XMLSchema#string

Maki Kubo

http://www.w3.org/2001/XMLSchema#string

Masami Masuda-Suzukake

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Masato Hasegawa

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P2860

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

Staging of brain pathology related to sporadic Parkinson's disease

Alpha-synuclein and neurodegenerative diseases

Distinct α-synuclein strains differentially promote tau inclusions in neurons

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

Trans-synaptic spread of tau pathology in vivo

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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2

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Masato Hosokawa

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2014-08-06T00:00:00Z

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