The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function
about
Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experimentsFrom structure to redox: The diverse functional roles of disulfides and implications in disease.von Willebrand factor: more than a regulator of hemostasis and thrombosis.Conformational activation of ADAMTS13.A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor.von Willebrand factor, Jedi knight of the bloodstreamUnraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.Mechanisms by which von Willebrand disease mutations destabilize the A2 domainThe molecular genetics of von Willebrand diseaseControl of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF.Biology and physics of von Willebrand factor concatamers.Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding.N-linked glycan stabilization of the VWF A2 domainA common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.ADAMTS-13 and von Willebrand factor: a dynamic duo.Autoregulation of von Willebrand factor function by a disulfide bond switch.The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.Long-ranged Protein-glycan Interactions Stabilize von Willebrand Factor A2 Domain from Mechanical UnfoldingDestabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations
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P2860
The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function
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2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
The importance of vicinal cyst ...... rand factor A2 domain function
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The importance of vicinal cyst ...... rand factor A2 domain function
@en
The importance of vicinal cyst ...... rand factor A2 domain function
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type
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The importance of vicinal cyst ...... rand factor A2 domain function
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The importance of vicinal cyst ...... rand factor A2 domain function
@en
The importance of vicinal cyst ...... rand factor A2 domain function
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prefLabel
The importance of vicinal cyst ...... rand factor A2 domain function
@ast
The importance of vicinal cyst ...... rand factor A2 domain function
@en
The importance of vicinal cyst ...... rand factor A2 domain function
@nl
P2093
P2860
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P1476
The importance of vicinal cyst ...... rand factor A2 domain function
@en
P2093
David A Lane
Jonas Emsley
Luke Y N Winn
P2860
P304
P356
10.1182/BLOOD-2009-12-257949
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P577
2010-03-30T00:00:00Z