Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
about
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress responseHomeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activationDynamic regulation of p53 subnuclear localization and senescence by MORC3Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damageRoles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formationThe WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsHomeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiationPossible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSHUbiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activationMyeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia proteinHow cells switch HIPK2 on and offThe human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrestp53 mediates the negative regulation of MDM2 by orphan receptor TR3Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesisMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayHIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionCyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylationWnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLKAlterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53The role of cullin 5-containing ubiquitin ligasesApoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2The function, regulation and therapeutic implications of the tumor suppressor protein, PMLRole of HIPK2 in kidney fibrosisHIPK2 is a new drug target for anti-fibrosis therapy in kidney diseaseAnother fork in the road--life or death decisions by the tumour suppressor p53An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelDesumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the EpigenomeEngagement of DYRK2 in proper control for cell divisionp53 Acetylation: Regulation and ConsequencesTargeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alphaOverlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neuronsInteraction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survivalSpatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expressionAxin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
P2860
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P2860
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@ast
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@en
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@nl
type
label
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@ast
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@en
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@nl
prefLabel
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@ast
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@en
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.
@nl
P2093
P2860
P50
P356
P1433
P1476
Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis
@en
P2093
Barbara Cecchinelli
Ettore Appella
Isabella Manni
Maurizio Fanciulli
Monica Gostissa
Sabrina Coen
Shin'ichi Saito
Tiziana Bruno
P2860
P2888
P356
10.1038/NCB714
P577
2002-01-01T00:00:00Z
P5875
P6179
1037784413