Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. - Wikidata - awgldk - TriplyDB

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

http://www.wikidata.org/entity/Q34108288

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Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation Dynamic regulation of p53 subnuclear localization and senescence by MORC3 Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1 AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein How cells switch HIPK2 on and off The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest p53 mediates the negative regulation of MDM2 by orphan receptor TR3 Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 The role of cullin 5-containing ubiquitin ligases Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 The function, regulation and therapeutic implications of the tumor suppressor protein, PML Role of HIPK2 in kidney fibrosis HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease Another fork in the road--life or death decisions by the tumour suppressor p53 An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome Engagement of DYRK2 in proper control for cell division p53 Acetylation: Regulation and Consequences Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

http://www.wikidata.org/entity/Q34108288

description

2002 nî lūn-bûn

@nan

2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@ast

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@en

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@nl

type

label

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@ast

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@en

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@nl

prefLabel

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@ast

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@en

Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis.

@nl

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P1433

Nature Cell Biology

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Homeodomain-interacting protei ...... Ser 46 and mediates apoptosis

@en

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Barbara Cecchinelli

http://www.w3.org/2001/XMLSchema#string

Ettore Appella

http://www.w3.org/2001/XMLSchema#string

Isabella Manni

http://www.w3.org/2001/XMLSchema#string

Maurizio Fanciulli

http://www.w3.org/2001/XMLSchema#string

Monica Gostissa

http://www.w3.org/2001/XMLSchema#string

Sabrina Coen

http://www.w3.org/2001/XMLSchema#string

Shin'ichi Saito

http://www.w3.org/2001/XMLSchema#string

Tiziana Bruno

http://www.w3.org/2001/XMLSchema#string

P2860

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Regulation of p53 activity in nuclear bodies by a specific PML isoform

A model for p53-induced apoptosis

Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

Surfing the p53 network

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

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11-19

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scholarly article

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10.1038/NCB714

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1

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4

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Yuichiro Higashimoto

Giannino Del Sal

Alessandra Marchetti

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2002-01-01T00:00:00Z

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232793683

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1037784413

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11780126

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phosphorylation