alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells.
about
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteinsCrystal structure of human DJ-1, a protein associated with early onset Parkinson's diseaseAlpha-synuclein structure, functions, and interactionsα-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activityInsights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Combined immunotherapy with "anti-insulin resistance" therapy as a novel therapeutic strategy against neurodegenerative diseases.Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease.Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseasesNonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodiesDieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system.Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection.Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta.Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways.Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells.Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's diseaseMolecular mechanisms of alpha-synuclein neurodegeneration.Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches.Antioxidant gene therapy against neuronal cell death.Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's DiseaseSynucleins: are they two-edged swords?Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?Interactions between calcium and alpha-synuclein in neurodegeneration.Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies.Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells.α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway.Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy.Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability.Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease.Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress
P2860
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P2860
alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@ast
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@en
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@nl
type
label
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@ast
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@en
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@nl
prefLabel
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@ast
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@en
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@nl
P2093
P356
P1476
alpha-Synuclein protects again ...... ing pathway in neuronal cells.
@en
P2093
Leigh J Hsu
Makoto Hashimoto
Margaret Mallory
Takato Takenouchi
P304
11465-11472
P356
10.1074/JBC.M111428200
P407
P577
2002-01-14T00:00:00Z