Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseReduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's diseaseAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingNeuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent PerspectivesGenetically engineered mouse models of Parkinson's diseasep62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stressProtein degradation pathways in Parkinson's disease: curse or blessingVPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseEndonuclease G mediates α-synuclein cytotoxicity during Parkinson's diseaseNADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's diseaseSpermidine protects against α-synuclein neurotoxicity.Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changesGenetic regulation of alpha-synuclein mRNA expression in various human brain tissues.Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytesWatching worms whither: modeling neurodegeneration in C. elegans.Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicityGenetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study.Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Systems biology of the autophagy-lysosomal pathway.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin.The Interplay between Alpha-Synuclein Clearance and SpreadingCysteine cathepsins are essential in lysosomal degradation of α-synuclein.A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by RapamycinMannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregatesGlucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease.Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
P2860
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P2860
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@en
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@nl
type
label
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@en
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@nl
prefLabel
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@en
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@nl
P2093
P2860
P356
P1433
P1476
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
@en
P2093
David G Standaert
Donna Crabtree
Guy A Caldwell
Jianhua Zhang
John J Shacka
Ken C Walls
Kevin A Roth
Kim A Caldwell
Lisa D Speake
Lisheng Peng
P2860
P2888
P356
10.1186/1756-6606-1-17
P577
2008-11-21T00:00:00Z
P5875
P6179
1029430469