Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.
about
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screensA heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activationOpioid receptor trafficking and interaction in nociceptorsOpioid receptor heteromers in analgesiaIn vivo delta opioid receptor internalization controls behavioral effects of agonistsCrystal structure of the µ-opioid receptor bound to a morphinan antagonistMorphine for the treatment of pain in sickle cell diseaseLigand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-targetMembrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recyclingLabel-free integrative pharmacology on-target of opioid ligands at the opioid receptor familyRole of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.Internalization dissociates β2-adrenergic receptorsChronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.Opioid-receptor-heteromer-specific trafficking and pharmacology.Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.A genetic determinant of the striatal dopamine response to alcohol in menmicro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal.How to design an opioid drug that causes reduced tolerance and dependence.Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells.Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacologyChronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoidsOpioid receptor desensitization: mechanisms and its link to toleranceMembrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway.Can intellectualism stifle scientific discovery?G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance.Tolerance effects of non-steroidal anti-inflammatory drugs microinjected into central amygdala, periaqueductal grey, and nucleus raphe: Possible cellular mechanism.Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.High Efficacy but Low Potency of δ-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.Opioid receptor internalization contributes to dermorphin-mediated antinociceptionDistinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptorsMu-opioid receptor desensitization: is morphine different?Analgesic tolerance to microinjection of the micro-opioid agonist DAMGO into the ventrolateral periaqueductal gray.Involvement of protein kinase C in morphine tolerance at spinal levels of rats.Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.
P2860
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P2860
Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of opioid receptor ...... e by receptor oligomerization.
@ast
Regulation of opioid receptor ...... e by receptor oligomerization.
@en
Regulation of opioid receptor ...... e by receptor oligomerization.
@nl
type
label
Regulation of opioid receptor ...... e by receptor oligomerization.
@ast
Regulation of opioid receptor ...... e by receptor oligomerization.
@en
Regulation of opioid receptor ...... e by receptor oligomerization.
@nl
prefLabel
Regulation of opioid receptor ...... e by receptor oligomerization.
@ast
Regulation of opioid receptor ...... e by receptor oligomerization.
@en
Regulation of opioid receptor ...... e by receptor oligomerization.
@nl
P2093
P1433
P1476
Regulation of opioid receptor ...... e by receptor oligomerization.
@en
P2093
Jamie Fong
Jennifer L Whistler
P304
P356
10.1016/S0092-8674(02)00613-X
P407
P577
2002-01-01T00:00:00Z