Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. - Wikidata - awgldk - TriplyDB

Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.

Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.

http://www.wikidata.org/entity/Q34383602

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Opioid receptors: toward separation of analgesic from undesirable effects Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism Endocytosis and signalling: intertwining molecular networks Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.Opioid-receptor-heteromer-specific trafficking and pharmacology.micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal.How to design an opioid drug that causes reduced tolerance and dependence.Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion.Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray.Opioid receptor desensitization: mechanisms and its link to tolerance Change in functional selectivity of morphine with the development of antinociceptive tolerance.Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance.The delta opioid receptor: an evolving target for the treatment of brain disorders.Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.Opioid receptor internalization contributes to dermorphin-mediated antinociception Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Ligand-directed signalling within the opioid receptor family.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors.Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area.Divergent modes for cargo-mediated control of clathrin-coated pit dynamics In vivo trafficking of endogenous opioid receptors.Functional characterization of human variants of the mu-opioid receptor gene Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.Regulation of opioid receptor signalling: implications for the development of analgesic tolerance.Opioid receptor trafficking and signaling: what happens after opioid receptor activation?Evidence from basic research for opioid combinations.Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.Morphine-like opiates selectively antagonize receptor-arrestin interactions.Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors.An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.The doctor's dilemma: opiate analgesics and chronic pain.

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P2860

Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.

http://www.wikidata.org/entity/Q34383602

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年论文

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name

Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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J.CUB.2007.12.057

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Current Biology

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Morphine-induced receptor endo ...... uces tolerance and dependence.

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Amy M Chang

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Carsten K Nielsen

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Chrissi J Ou

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Dragana Cado

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Jennifer L Whistler

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Joseph A Kim

http://www.w3.org/2001/XMLSchema#string

Li He

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Madeline Ferwerda

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Maria Waldhoer

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Selena Bartlett

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P2860

Enhanced morphine analgesia in mice lacking beta-arrestin 2

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.

Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine.

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization.

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.

Morphine activates opioid receptors without causing their rapid internalization.

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129-135

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10.1016/J.CUB.2007.12.057

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2

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18

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5643461

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18207746

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2997702

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