In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activityDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseDevelopments in the treatment of visceral leishmaniasisThematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylationMetabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental AnalysisBisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme dataWater-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum.Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis.Therapeutic switching in leishmania chemotherapy: a distinct approach towards unsatisfied treatment needs.2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthaseQuinuclidine derivatives as potential antiparasiticsMolecular characterization of farnesyl pyrophosphate synthase from Bacopa monniera by comparative modeling and docking studies.Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii.The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan ParasitesDrugs in development for toxoplasmosis: advances, challenges, and current status.New antibacterials for the treatment of toxoplasmosis; a patent review.The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.Protective immunity using MPL-A and autoclaved Leishmania donovani as adjuvants along with a cocktail vaccine in murine model of visceral leishmaniasis.Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.
P2860
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P2860
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@ast
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@en
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@nl
type
label
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@ast
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@en
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@nl
prefLabel
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@ast
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@en
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@nl
P2093
P2860
P1476
In vivo activities of farnesyl ...... onovani and Toxoplasma gondii.
@en
P2093
Anis A Khan
Eric Oldfield
Fausto G Araujo
Michael B Martin
Roberto Docampo
Silvia N J Moreno
Simon L Croft
Teri R Slifer
Vanessa Yardley
P2860
P304
P356
10.1128/AAC.46.3.929-931.2002
P407
P577
2002-03-01T00:00:00Z