Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
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A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemiaHampering immune suppressors: therapeutic targeting of myeloid-derived suppressor cells in cancerFunctional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer ProgressionSystemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial InfarctionRNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib.Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer.Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis.Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way.Innate immune regulation by STAT-mediated transcriptional mechanisms.Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.Evidence for cFMS signaling in HIV production by brain macrophages and microglia.Macrophage depletion ameliorates nephritis induced by pathogenic antibodies.Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendritesMRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticlesCSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor GrowthTyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosisAutocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth.Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancerNilotinib protects the murine liver from ischemia/reperfusion injury.The use of novel selectivity metrics in kinase research.Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophagesMacrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian CancerBone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks.Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34.Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survivalTargeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responsesCSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves.Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophagesPolyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccinesCoordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma.IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer.Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents.Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis.
P2860
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P2860
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@ast
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@en
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@nl
type
label
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@ast
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@en
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@nl
prefLabel
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@ast
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@en
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@nl
P2093
P2860
P356
P1476
Inhibition of colony-stimulati ...... cFMS kinase inhibitor GW2580.
@en
P2093
Alan Payne
Barry Keith
Bart Votta
Brad McDonald
David W Rusnak
Frederick C Kull
James G Conway
Janet Parham
P2860
P304
16078-16083
P356
10.1073/PNAS.0502000102
P407
P577
2005-10-25T00:00:00Z