Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression - Wikidata - awgldk - TriplyDB

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

http://www.wikidata.org/entity/Q34119822

about

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros The immunogenetics of primary biliary cirrhosis: A comprehensive review Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia The Ikaros family of zinc-finger proteins Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.IRF4 is a suppressor of c-Myc induced B cell leukemia.Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing.The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription A novel, non-canonical splice variant of the Ikaros gene is aberrantly expressed in B-cell lymphoproliferative disorders.Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Lymphocyte development: integration of DNA damage response signaling.A role for IRF4 in the development of CLL.A role for IRF8 in B cell anergy.Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.Balancing Proliferation with Igκ Recombination during B-lymphopoiesis Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Ikaros in immune receptor signaling, lymphocyte differentiation, and function.Ikaros and tumor suppression in acute lymphoblastic leukemia The diverse roles of IRF4 in late germinal center B-cell differentiation.B-lineage transcription factors and cooperating gene lesions required for leukemia development.B cell biology: an overview.IRF4 and IRF8: Governing the virtues of B Lymphocytes.Assembly and Function of the Precursor B-Cell Receptor.Signaling proteins and transcription factors in normal and malignant early B cell development.Cell cycle RNA regulons coordinating early lymphocyte development.FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

P2860

Q24301012-3B0FDE90-0487-48DA-AB97-8FD177BC3D3F Q24607867-19B86DEE-09B0-4310-AAE3-92F096E5E1FA Q26801377-A777F4F4-DCEE-48DF-AEEF-F79AFE0B40DE Q26862927-3BC40DE1-23D1-42B3-9F53-021FC536FF24 Q27025242-3C8B60CD-E26D-4BF2-944C-36D609182F27 Q28066194-66595B5F-24D2-4BD9-938C-EBA39DAAFEF7 Q28300080-1D41B0D6-1366-47B3-8DA4-5E9CFBBDC5ED Q28507888-9486F70C-99E2-442D-AB3D-13595C9453DC Q33551348-9DBA43F5-7F1A-432F-98C4-0E5A8A438A21 Q33983307-CB1B7C7D-F1F9-4140-BD6D-5848BE4EA856 Q34219169-9492E633-828F-441F-BB1E-C7A350D5FA05 Q34686905-70F9596F-85A1-402E-8104-4ABC95BFA569 Q34846643-671DA438-6455-45A9-B700-55416FC21F67 Q35064910-945BC2E3-F2B7-450C-AABE-64184174116B Q35105746-5E86F6EB-0829-45BB-BC08-4C52D0134960 Q35483709-0858DED0-EB29-4855-9B8F-E62D1972B3B0 Q35640007-A0C0AA8C-529A-4E64-8238-EB9AD430144D Q35796527-CAC1D713-2AE5-4C94-A6CE-E59EDE7FB974 Q36561755-EB845D6C-046A-4F81-8B31-94D421F93F4B Q36562871-9748C49D-4625-45C6-B341-DAB58AA4A036 Q36773380-3D5EFB75-726E-40D3-AD5A-97590D44EC33 Q36831332-7946A897-EEE3-459C-85BB-58BBDB4E8EB8 Q36837426-C2BF90C9-A5CC-4508-B8AF-BB46DBCAAA18 Q36846366-39953A8B-A6A8-436D-A3ED-965D5C5350A7 Q37235687-90CC0E02-37D3-4836-8279-FED1CE768D72 Q37394553-C9F0E4D2-7606-4BE3-8395-346041952A23 Q37397804-EC214C30-4D8B-4F52-9E23-5A0B06A69B7C Q37528135-4A220F50-FCE6-48DE-AC55-C4A86671022C Q37692925-845F2427-688E-4550-88F3-801392F30DA2 Q37713982-E48D06CD-8141-4207-9E93-ED88A70A83F9 Q37796303-E7F90EA5-1565-4CA6-8356-4BE3EF157932 Q37965798-E3F668A0-6C87-4962-8E98-B71236856FBE Q38002486-80418296-92AB-4998-8BEC-8BB25662A867 Q38050656-E5C0DA11-DFC8-4B71-B582-75A15151DAB5 Q38196333-2E64E480-69EA-4FA5-9017-A6149A7734AF Q38288293-B0BC01B0-7C14-448E-9174-B53476DD9045 Q38594687-441BAB18-B697-4D9B-B7D1-0B155E28A1CA Q38804856-35E39CDB-056E-4F1F-9B0B-D3FCD4170CC4 Q39148241-AFD0A5E7-491F-4327-8B57-045A9F1E78F9 Q41182606-192740E6-D0C7-4CCE-9BA0-9801F707B935

P2860

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

http://www.wikidata.org/entity/Q34119822

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@ast

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@en

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@nl

type

label

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@ast

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@en

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@nl

prefLabel

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@ast

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@en

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@nl

P1433

Q34119822-2AB33530-8ECE-4946-84AE-3BC954419687

P1476

Q34119822-BF78F24D-1B80-499D-9C08-3DB86C428643

P2093

Q34119822-105682B7-1063-4598-B439-CA426AEA7ECB

Q34119822-231A0300-CC03-4CD9-9757-EB934855571F

Q34119822-27354D22-59C2-49B6-A70B-23EA76C96647

Q34119822-370C431D-ACD4-4ACB-81B3-FB78639A4DA2

Q34119822-54429B52-C244-4F90-9BBA-C42D9499E250

Q34119822-63FEEA01-3812-4E25-8BBD-6802E945AE5E

P2860

Q34119822-020779A0-7D85-4865-9E1E-A4705A863B1D

Q34119822-07B9A4E7-3346-46A6-A1A0-0E5634F83ED8

Q34119822-1A659C88-C345-421F-A7F9-2D1884E01023

Q34119822-1CB44356-C99F-4420-B9E3-E7B06EF984E2

Q34119822-28667E7D-5545-40E8-9D32-B1F9BBA5E9FC

Q34119822-3501B9C9-18FD-4891-832D-1644A46413E0

Q34119822-3C493D4F-690D-4C77-B917-33A738DDBB25

Q34119822-4BA50D47-1E0B-4EE2-A04C-C08EE0480B16

Q34119822-59102C55-16A3-4FFA-83FD-076A1E9FF8B6

Q34119822-5EFF9FD5-1A6D-4A50-92F8-2D9D32A6C59B

P304

Q34119822-A6721DBA-98E0-446D-B80A-15E085766A84

P31

Q34119822-24CFFD76-E178-477E-A556-11068D9DDA13

P356

Q34119822-DF540309-07D3-4FCB-9E33-6075A32A8BFF

P407

Q34119822-C3978460-E456-4396-A23E-2370E06E9D25

P433

Q34119822-A2FBF5F8-2AB7-4A5B-A6E2-822266C26BF0

P478

Q34119822-16AFC336-7C88-444D-A596-5EC25CECA0FC

P577

Q34119822-F14089A3-4F64-41CA-A933-B02986CFD369

P698

Q34119822-08F911AB-AFB8-4FF3-8817-FC1A187855C0

P932

Q34119822-8E5480DA-3C15-422C-AA63-7D214F05494F

P356

P1433

Molecular and Cellular Biology

P1476

Ikaros and Aiolos inhibit pre- ...... y suppressing c-Myc expression

@en

P2093

Long Trinh

http://www.w3.org/2001/XMLSchema#string

Malay Mandal

http://www.w3.org/2001/XMLSchema#string

Marcus R Clark

http://www.w3.org/2001/XMLSchema#string

Runqing Lu

http://www.w3.org/2001/XMLSchema#string

Shibin Ma

http://www.w3.org/2001/XMLSchema#string

Simanta Pathak

http://www.w3.org/2001/XMLSchema#string

P2860

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

Aiolos regulates B cell activation and maturation to effector state

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

Interferon regulatory factor 4 and 8 in B-cell development.

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.

Haematopoietic cell-fate decisions, chromatin regulation and ikaros.

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation

P304

4149-4158

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.00224-10

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

30

http://www.w3.org/2001/XMLSchema#string

P577

2010-06-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20566697

http://www.w3.org/2001/XMLSchema#string

P932

2937562

http://www.w3.org/2001/XMLSchema#string