Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development - Wikidata - awgldk - TriplyDB

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

http://www.wikidata.org/entity/Q24561965

about

ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature Cell cycle-specific function of Ikaros in human leukemia Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Genetic abnormalities associated with acute lymphoblastic leukemia Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator Dosage-dependent requirement for mouse Vezf1 in vascular system development Multiple hematopoietic defects and delayed globin switching in Ikaros null mice Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz.Ikaros integrates endocrine and immune system development Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation Ikaros SUMOylation: switching out of repression Loss of B Cells in Patients with Heterozygous Mutations in IKAROS.Transcription factor Ikaros represses protein phosphatase 2A (PP2A) expression through an intronic binding site.Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity.An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III.Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases Design of polyzinc finger peptides with structured linkers.Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.Dissecting teleost B cell differentiation using transcription factors.Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.Regulator of myeloid differentiation and function: The secret life of Ikaros.Ikaros isoforms: The saga continues.Vasoactive intestinal peptide signaling axis in human leukemia.Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.

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P2860

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

http://www.wikidata.org/entity/Q24561965

description

1996 nî lūn-bûn

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1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1996 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1996年の論文

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年學術文章

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Zinc finger-mediated protein i ...... trol of lymphocyte development

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Zinc finger-mediated protein i ...... trol of lymphocyte development

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The EMBO Journal

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Zinc finger-mediated protein i ...... trol of lymphocyte development

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P2093

A Liu

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K Georgopoulos

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L Sun

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P2860

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains

Purification of early-B-cell factor and characterization of its DNA-binding specificity

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

Three-dimensional solution structure of a single zinc finger DNA-binding domain

Rapid and efficient site-specific mutagenesis without phenotypic selection

A novel genetic system to detect protein-protein interactions

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19

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15

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452279

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