The sterol-sensing domain: multiple families, a unique role?
about
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomesMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionDISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolismThe hedgehog receptor patched is involved in cholesterol transportMice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic developmentPhyloDome--visualization of taxonomic distributions of domains occurring in eukaryote protein sequence setsThe function and expansion of the Patched- and Hedgehog-related homologs in C. elegansDifferential range and activity of various forms of the Hedgehog proteinDual functions of Insig proteins in cholesterol homeostasisINSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteinsIsolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseMice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasiaMethylation at the C-2 position of hopanoids increases rigidity in native bacterial membranesFunctional characterization of the MENTAL domain.Side-chain oxysterols: from cells to membranes to molecules.Smoothened goes molecular: new pieces in the hedgehog signaling puzzleThe hedgehog signaling pathway: where did it come from?Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid BilayersCholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change.NPC1L1 and cholesterol transportGenetic connections between neurological disorders and cholesterol metabolismDeficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductaseSignaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction.Niemann-Pick type C disease and intracellular cholesterol trafficking.Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranesC. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domainFunctional requirements driving the gene duplication in 12 Drosophila species.Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish.Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liverThe sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.The Hedgehog signaling pathway--implications for drug targets in cancer and neurodegenerative disorders.Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.Protein mediators of sterol transport across intestinal brush border membrane.Dependence receptors: mechanisms of an announced death.PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.
P2860
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P2860
The sterol-sensing domain: multiple families, a unique role?
description
2002 nî lūn-bûn
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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The sterol-sensing domain: multiple families, a unique role?
@ast
The sterol-sensing domain: multiple families, a unique role?
@en
The sterol-sensing domain: multiple families, a unique role?
@nl
type
label
The sterol-sensing domain: multiple families, a unique role?
@ast
The sterol-sensing domain: multiple families, a unique role?
@en
The sterol-sensing domain: multiple families, a unique role?
@nl
prefLabel
The sterol-sensing domain: multiple families, a unique role?
@ast
The sterol-sensing domain: multiple families, a unique role?
@en
The sterol-sensing domain: multiple families, a unique role?
@nl
P1433
P1476
The sterol-sensing domain: multiple families, a unique role?
@en
P2093
Michel Labouesse
Patricia E Kuwabara
P304
P356
10.1016/S0168-9525(02)02640-9
P577
2002-04-01T00:00:00Z