NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).
about
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylationHigh-resolution genomic profiles of human lung cancerTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyHistone methyltransferases: novel targets for tumor and developmental defectsEpigenomics of leukemia: from mechanisms to therapeutic applicationsPartners in crime: The role of tandem modules in gene transcriptionGain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionThe Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 RecognitionIdentification of ID-1 as a potential target gene of MMSET in multiple myelomaThe role of NUP98 gene fusions in hematologic malignancyNizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motifNSD1 is essential for early post-implantation development and has a catalytically active SET domainMethylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase IIBiomarkers of genome instability and cancer epigenetics.NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia.Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.Role of the nuclear envelope in genome organization and gene expression.Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity.In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.Transforming properties of 8p11-12 amplified genes in human breast cancer.The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Genetic alterations of histone lysine methyltransferases and their significance in breast cancerNUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsInhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies.Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique.NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.Histone demethylases and cancer.Cancer genetics of epigenetic genes.A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.Epigenetic regulation of normal and malignant hematopoiesis.PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.Nuclear pore proteins and cancerEpigenetics of hematopoiesis and hematological malignancies.WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.Understanding the language of Lys36 methylation at histone H3.Transcriptional and epigenetic networks in haematological malignancy.
P2860
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P2860
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t
@nl
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@ast
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@en
type
label
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t
@nl
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@ast
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@en
prefLabel
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t
@nl
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@ast
NUP98 is fused to the NSD3 gen ...... iated with t(8;11)(p11.2;p15).
@en
P2093
P1433
P1476
NUP98 is fused to the NSD3 gen ...... ciated with t(8;11)(p11.2;p15)
@en
P2093
Ana Aventin
Christine Schwienbacher
Cristina Mecucci
Massimo F Martelli
Massimo Negrini
Roberta La Starza
Roberto Rosati
Teresa Vallespi
P304
P356
10.1182/BLOOD.V99.10.3857
P407
P577
2002-05-01T00:00:00Z