PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. - Wikidata - awgldk - TriplyDB

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

http://www.wikidata.org/entity/Q37235746

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Biochemical profiling of histone binding selectivity of the yeast bromodomain family The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9 ABL tyrosine kinases: evolution of function, regulation, and specificity Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain Histone recognition and large-scale structural analysis of the human bromodomain family TRIM24 links a non-canonical histone signature to breast cancer Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers The Structural Determinants behind the Epigenetic Role of Histone Variants Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression NMR structure note: PHD domain from death inducer obliterator protein and its interaction with H3K4me3 Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia Chd5 requires PHD-mediated histone 3 binding for tumor suppression Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma PHF6 mutations in T-cell acute lymphoblastic leukemia Quantitative proteomic analysis of histone modifications The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Combinatorial profiling of chromatin binding modules reveals multisite discrimination.A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.Epigenetics: an emerging player in gastric cancer PHD fingers: epigenetic effectors and potential drug targets Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation Druggability of methyl-lysine binding sites.GmPHD5 acts as an important regulator for crosstalk between histone H3K4 di-methylation and H3K14 acetylation in response to salinity stress in soybean Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation High-throughput strategy to identify inhibitors of histone-binding domains.Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3 Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.NSD1 mitigates caspase-1 activation by listeriolysin O in macrophages JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study

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PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

http://www.wikidata.org/entity/Q37235746

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 July 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@en

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@nl

type

label

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@en

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@nl

prefLabel

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@en

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

@nl

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J.MRFMMM.2008.07.004

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Mutation Research

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PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

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C David Allis

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Gang G Wang

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Lindsey A Baker

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P2860

Alpha thalassaemia-mental retardation, X linked

Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

Cloning and characterization of a new human Xq13 gene, encoding a putative helicase

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3-12

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scholarly article

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10.1016/J.MRFMMM.2008.07.004

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1-2

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2008-07-17T00:00:00Z

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2656448

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