Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.
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ABC transporter function and regulation at the blood-spinal cord barrierDrug delivery systems, CNS protection, and the blood brain barrierNrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriersFunctional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.Regulation of ABC transporters at the blood-brain barrier.Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Engaging neuroscience to advance translational research in brain barrier biology.Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.Deciphering the roles of the constitutive androstane receptor in energy metabolism.In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brainRegulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier.1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cellsTargeted drug delivery to treat pain and cerebral hypoxiaFunctional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.Compartment-specific gene regulation of the CAR inducer efavirenz in vivo.Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanismA retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.The blood-brain barrier: an engineering perspective.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.ABC transporters at the blood-brain barrier.Transendothelial Transport and Its Role in Therapeutics.Temporal expression of transporters and receptors in a rat primary co-culture blood-brain barrier model.Marked differences in the effect of antiepileptic and cytostatic drugs on the functionality of P-glycoprotein in human and rat brain capillary endothelial cell lines.Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.Tissue distribution and phenobarbital induction of target SLC- and ABC- transporters in cattle.PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.Obstacles to Brain Tumor Therapy: Key ABC Transporters.Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood-brain barrier.Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?
P2860
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P2860
Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Constitutive androstane recept ...... rs at the blood-brain barrier.
@ast
Constitutive androstane recept ...... rs at the blood-brain barrier.
@en
Constitutive androstane recept ...... rs at the blood-brain barrier.
@nl
type
label
Constitutive androstane recept ...... rs at the blood-brain barrier.
@ast
Constitutive androstane recept ...... rs at the blood-brain barrier.
@en
Constitutive androstane recept ...... rs at the blood-brain barrier.
@nl
prefLabel
Constitutive androstane recept ...... rs at the blood-brain barrier.
@ast
Constitutive androstane recept ...... rs at the blood-brain barrier.
@en
Constitutive androstane recept ...... rs at the blood-brain barrier.
@nl
P2860
P356
P1476
Constitutive androstane recept ...... rs at the blood-brain barrier.
@en
P2093
Destiny B Sykes
Xueqian Wang
P2860
P304
P356
10.1124/MOL.110.063685
P577
2010-06-14T00:00:00Z