about
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsCritical role of toxicologic pathology in a short-term screen for carcinogenicityMolecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorProteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.Multi-species analyses of direct activators of the constitutive androstane receptor.Nuclear receptors in nonalcoholic Fatty liver diseaseRNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Genomic profiling in nuclear receptor-mediated toxicity.The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk.Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-drug Interactions in Adult Life.Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver.Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoformInvolvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.Introduction to hepatic drug metabolizing enzyme induction in drug safety evaluation studies.Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants.Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.Mode of action in relevance of rodent liver tumors to human cancer risk.Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Functional and structural comparison of PXR and CAR.
@ast
Functional and structural comparison of PXR and CAR.
@en
type
label
Functional and structural comparison of PXR and CAR.
@ast
Functional and structural comparison of PXR and CAR.
@en
prefLabel
Functional and structural comparison of PXR and CAR.
@ast
Functional and structural comparison of PXR and CAR.
@en
P2093
P1476
Functional and structural comparison of PXR and CAR.
@en
P2093
Jodi M Maglich
John T Moore
Linda B Moore
Steve A Kliewer
P304
P356
10.1016/S0304-4165(02)00481-6
P407
P577
2003-02-01T00:00:00Z