CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor - Wikidata - awgldk - TriplyDB

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

http://www.wikidata.org/entity/Q34131886

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Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) alters early embryonic development in a rat IVF exposure model.Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.PCB153-induced overexpression of ID3 contributes to the development of microvascular lesions Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.Activation of the aryl hydrocarbon receptor by doxorubicin mediates cytoprotective effects in the heart Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding.Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities.Induction of AhR-mediated gene transcription by coffee.The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines.Aryl hydrocarbon receptor ligands in cancer: friend and foe.The aryl hydrocarbon receptor regulates an essential transcriptional element in the immunoglobulin heavy chain gene.Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts.Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.Co-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression.Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells.The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia.Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor.Immunoanalysis methods for the detection of dioxins and related chemicals.Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1 AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro.Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target.Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells.Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes.The aryl hydrocarbon receptor controls cell-fate decisions in B cells.Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis.Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.Aryl hydrocarbon receptor (AhR) attenuation of subchronic cigarette smoke-induced pulmonary neutrophilia is associated with retention of nuclear RelB and suppression of intercellular adhesion molecule-1 (ICAM-1).Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis.The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.

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CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

http://www.wikidata.org/entity/Q34131886

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@ast

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@en

CH223191 is a ligand-selective antagonist of the Ah

@nl

type

label

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@ast

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@en

CH223191 is a ligand-selective antagonist of the Ah

@nl

prefLabel

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@ast

CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@en

CH223191 is a ligand-selective antagonist of the Ah

@nl

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P1433

Toxicological Sciences

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CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor

@en

P2093

Ai Hayashi

http://www.w3.org/2001/XMLSchema#string

Bin Zhao

http://www.w3.org/2001/XMLSchema#string

Danica E Degroot

http://www.w3.org/2001/XMLSchema#string

Guochun He

http://www.w3.org/2001/XMLSchema#string

Michael S Denison

http://www.w3.org/2001/XMLSchema#string

P2860

Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

Ligand binding and activation of the Ah receptor

Estrogen and progesterone receptors: from molecular structures to clinical targets

Identification of amino acid residues in the Ah receptor involved in ligand binding

The aryl hydrocarbon receptor complex and the control of gene expression

2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity

Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.

Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.

Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone

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393-403

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scholarly article

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10.1093/TOXSCI/KFQ217

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2

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117

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2010-07-15T00:00:00Z

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45199867

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20634293

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2940411

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