A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
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T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T CellsIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensThe Timing of T Cell Priming and CyclingThe role of T cell receptor signaling thresholds in guiding T cell fate decisionsTumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection.Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.Protein networks and activation of lymphocytes.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar AntigensRapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis.Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses.Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection.Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.Low-affinity CD4+ T cells are major responders in the primary immune responseTargeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances.Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.Antigen Availability and DOCK2-Driven Motility Govern CD4+ T Cell Interactions with Dendritic Cells In Vivo.Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ.Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo.Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.Tonic Signals: Why Do Lymphocytes Bother?IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.Microvesicles released by apoptotic human neutrophils suppress proliferation and IL-2/IL-2 receptor expression of resting T helper cells.Modulation of Naive CD8 T Cell Response Features by Ligand Density, Affinity, and Continued Signaling via Internalized TCRs.Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes.Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis.2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 EpitopesExpanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
P2860
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P2860
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
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2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@ast
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@en
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@nl
type
label
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@ast
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@en
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@nl
prefLabel
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@ast
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@en
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@nl
P2093
P2860
P50
P356
P1476
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
@en
P2093
Arthur Weiss
Debra A Cheng
James L Mueller
Kevan M Shokat
Mehrdad Matloubian
Yiling Chen
P2860
P304
P356
10.1073/PNAS.1413726111
P407
P577
2014-08-18T00:00:00Z