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The role of T cell receptor signaling thresholds in guiding T cell fate decisionsCIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes InfectionDistinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.The structure, regulation, and function of ZAP-70.Itk controls the spatiotemporal organization of T cell activation.Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTLZAP-70: an essential kinase in T-cell signalingA genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.A key role for Itk in both IFN gamma and IL-4 production by NKT cells.Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector functionAdaptation by naïve CD4+ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Byron B Au-Yeung
@ast
Byron B Au-Yeung
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Byron B Au-Yeung
@es
Byron B Au-Yeung
@nl
Byron B Au-Yeung
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type
label
Byron B Au-Yeung
@ast
Byron B Au-Yeung
@en
Byron B Au-Yeung
@es
Byron B Au-Yeung
@nl
Byron B Au-Yeung
@sl
prefLabel
Byron B Au-Yeung
@ast
Byron B Au-Yeung
@en
Byron B Au-Yeung
@es
Byron B Au-Yeung
@nl
Byron B Au-Yeung
@sl
P106
P108
P21
P31
P496
0000-0002-6446-9102
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2000-01-01T00:00:00Z