Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
about
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selectionAutoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residueT cell receptor signalling in the control of regulatory T cell differentiation and functionTCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of DifferentiationThymus, innate immunity and autoimmune arthritis: interplay of gene and environmentStructural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerA novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitisThe Structural Basis for Activation and Inhibition of ZAP-70 Kinase DomainDiscovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.Impact of the TCR signal on regulatory T cell homeostasis, function, and traffickingIdd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cellsDissecting mammalian immunity through mutation.Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo.Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cellsWhy is PTPN22 a good candidate susceptibility gene for autoimmune disease?Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody productionA sharp T-cell antigen receptor signaling threshold for T-cell proliferation.Control of central and peripheral tolerance by Aire.Detection of T cell responses to a ubiquitous cellular protein in autoimmune diseaseImmunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.The genetic basis of graves' disease.A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Partial defects of T-cell development associated with poor T-cell function.The janus head of T cell aging - autoimmunity and immunodeficiency.Lymphocyte signaling: beyond knockouts.SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complexEarly onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
P2860
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P2860
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Opposing functions of the T ce ...... e to nucleotide substitutions.
@ast
Opposing functions of the T ce ...... e to nucleotide substitutions.
@en
type
label
Opposing functions of the T ce ...... e to nucleotide substitutions.
@ast
Opposing functions of the T ce ...... e to nucleotide substitutions.
@en
prefLabel
Opposing functions of the T ce ...... e to nucleotide substitutions.
@ast
Opposing functions of the T ce ...... e to nucleotide substitutions.
@en
P2093
P2860
P50
P1433
P1476
Opposing functions of the T ce ...... se to nucleotide substitutions
@en
P2093
Adèle L Yates
Daniel Sheahan
Edyta M Kucharska
Lisa A Miosge
P2860
P304
P356
10.1016/J.IMMUNI.2007.11.013
P407
P577
2007-12-01T00:00:00Z