Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.
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Spatio-temporal simulation of first pass drug perfusion in the liverPhysiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model VerificationA mechanistic, model-based approach to safety assessment in clinical developmentIntegrating cellular metabolism into a multiscale whole-body modelRepresentative Sinusoids for Hepatic Four-Scale Pharmacokinetics SimulationsModel-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.Clinical translation in the virtual liver networkThe role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development.A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.Wind of change challenges toxicological regulators.A detailed physiologically based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine Renin-Angiotensin-aldosterone systemMathematical modeling of folate metabolism.Physiologically based pharmacokinetic modelling and in vivo [I]/K(i) accurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate.Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions.The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives.Transporters as Drug Targets in Neurological DiseasesPhysiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid.The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.Patulin in apple juice and its risk assessments on albino mice.Highlight report: physiologically-based modeling of diseased liver tissue.Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation.Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situationsPBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and DigoxinPhysiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO
P2860
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P2860
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Using expression data for quan ...... ased pharmacokinetic modeling.
@ast
Using expression data for quan ...... ased pharmacokinetic modeling.
@en
Using expression data for quan ...... ased pharmacokinetic modeling.
@nl
type
label
Using expression data for quan ...... ased pharmacokinetic modeling.
@ast
Using expression data for quan ...... ased pharmacokinetic modeling.
@en
Using expression data for quan ...... ased pharmacokinetic modeling.
@nl
prefLabel
Using expression data for quan ...... ased pharmacokinetic modeling.
@ast
Using expression data for quan ...... ased pharmacokinetic modeling.
@en
Using expression data for quan ...... ased pharmacokinetic modeling.
@nl
P2093
P356
P1476
Using expression data for quan ...... ased pharmacokinetic modeling.
@en
P2093
Bernd Ludewig
Joerg Lippert
Michaela Meyer
Sebastian Schneckener
P304
P356
10.1124/DMD.111.043174
P50
P577
2012-01-31T00:00:00Z